Genes and environment in neonatal intraventricular hemorrhage

Laura R. Ment; Ulrika Ådén; Charles R. Bauer; Henrietta S. Bada; Waldemar A. Carlo; Jeffrey R. Kaiser; Aiping Lin; Charles Michael Cotten; Jeffrey Murray; Grier Page; Mikko Hallman; Richard P. Lifton; Heping Zhang; Cindy Bryant; Christopher Cassady; Carmen Garcia; Yvette R. Johnson; Heidi E. Karpen; Martha M. Munden; Geneva Shores; John Cassese; Angelita M. Hensman; Elisa Vieira; Betty Vohr; Michael Wallach; James J. Cummings; Scott S. MacGilvray; Sherry Moseley; Vickie Trapanotto; Brenda Poindexter; Leslie Dawn Wilson; Shirley Wright-Coltart; Marco Bartocci; Gordana Printz; Andrew Hopper; Leon Smith; Beverly P. Wood; Lionel Young; Walter C. Allan; Jessica Alfsson; Karin Sävman; Stuart A. Royal; Daniel W. Young; Shirley Cosby; Crystal Helms; Teresita Angtuaco; N. Carol Sikes; Melanie J. Mason; R. Whit Hall; Harris L. Cohen; Gene targets for IVH study group; Neonatal research network genomics study group

doi:10.1053/j.semperi.2015.09.006

Genes and environment in neonatal intraventricular hemorrhage

Laura R. Ment
, Ulrika Ådén
, Charles R. Bauer
, Henrietta S. Bada
, Waldemar A. Carlo
, Jeffrey R. Kaiser
, Aiping Lin
, Charles Michael Cotten
, Jeffrey Murray
, Grier Page
, Mikko Hallman
, Richard P. Lifton
, Heping Zhang
, Cindy Bryant
, Christopher Cassady
, Carmen Garcia
, Yvette R. Johnson
, Heidi E. Karpen
, Martha M. Munden
, Geneva Shores

John Cassese, Angelita M. Hensman, Elisa Vieira, Betty Vohr, Michael Wallach, James J. Cummings, Scott S. MacGilvray, Sherry Moseley, Vickie Trapanotto, Brenda Poindexter, Leslie Dawn Wilson, Shirley Wright-Coltart, Marco Bartocci, Gordana Printz, Andrew Hopper, Leon Smith, Beverly P. Wood, Lionel Young, Walter C. Allan, Jessica Alfsson, Karin Sävman, Stuart A. Royal, Daniel W. Young, Shirley Cosby, Crystal Helms, Teresita Angtuaco, N. Carol Sikes, Melanie J. Mason, R. Whit Hall, Harris L. Cohen, Gene targets for IVH study group, Neonatal research network genomics study group

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

Original language	English (US)
Pages (from-to)	592-603
Number of pages	12
Journal	Seminars in Perinatology
Volume	39
Issue number	8
DOIs	https://doi.org/10.1053/j.semperi.2015.09.006
State	Published - Dec 1 2015
Externally published	Yes

Keywords

Genes
GWAS
Intraventricular hemorrhage
Neonate
Preterm

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

Access to Document

10.1053/j.semperi.2015.09.006

Cite this

Ment, L. R., Ådén, U., Bauer, C. R., Bada, H. S., Carlo, W. A., Kaiser, J. R., Lin, A., Cotten, C. M., Murray, J., Page, G., Hallman, M., Lifton, R. P., Zhang, H., Bryant, C., Cassady, C., Garcia, C., Johnson, Y. R., Karpen, H. E., Munden, M. M., ... Neonatal research network genomics study group (2015). Genes and environment in neonatal intraventricular hemorrhage. Seminars in Perinatology, 39(8), 592-603. https://doi.org/10.1053/j.semperi.2015.09.006

Ment, LR, Ådén, U, Bauer, CR, Bada, HS, Carlo, WA, Kaiser, JR, Lin, A, Cotten, CM, Murray, J, Page, G, Hallman, M, Lifton, RP, Zhang, H, Bryant, C, Cassady, C, Garcia, C, Johnson, YR, Karpen, HE, Munden, MM, Shores, G, Cassese, J, Hensman, AM, Vieira, E, Vohr, B, Wallach, M, Cummings, JJ, MacGilvray, SS, Moseley, S, Trapanotto, V, Poindexter, B, Wilson, LD, Wright-Coltart, S, Bartocci, M, Printz, G, Hopper, A, Smith, L, Wood, BP, Young, L, Allan, WC, Alfsson, J, Sävman, K, Royal, SA, Young, DW, Cosby, S, Helms, C, Angtuaco, T, Carol Sikes, N, Mason, MJ, Whit Hall, R, Cohen, HL, Gene targets for IVH study group & Neonatal research network genomics study group 2015, 'Genes and environment in neonatal intraventricular hemorrhage', Seminars in Perinatology, vol. 39, no. 8, pp. 592-603. https://doi.org/10.1053/j.semperi.2015.09.006

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title = "Genes and environment in neonatal intraventricular hemorrhage",

abstract = "Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.",

keywords = "Genes, GWAS, Intraventricular hemorrhage, Neonate, Preterm",

author = "Ment, \{Laura R.\} and Ulrika {\AA}d{\'e}n and Bauer, \{Charles R.\} and Bada, \{Henrietta S.\} and Carlo, \{Waldemar A.\} and Kaiser, \{Jeffrey R.\} and Aiping Lin and Cotten, \{Charles Michael\} and Jeffrey Murray and Grier Page and Mikko Hallman and Lifton, \{Richard P.\} and Heping Zhang and Cindy Bryant and Christopher Cassady and Carmen Garcia and Johnson, \{Yvette R.\} and Karpen, \{Heidi E.\} and Munden, \{Martha M.\} and Geneva Shores and John Cassese and Hensman, \{Angelita M.\} and Elisa Vieira and Betty Vohr and Michael Wallach and Cummings, \{James J.\} and MacGilvray, \{Scott S.\} and Sherry Moseley and Vickie Trapanotto and Brenda Poindexter and Wilson, \{Leslie Dawn\} and Shirley Wright-Coltart and Marco Bartocci and Gordana Printz and Andrew Hopper and Leon Smith and Wood, \{Beverly P.\} and Lionel Young and Allan, \{Walter C.\} and Jessica Alfsson and Karin S{\"a}vman and Royal, \{Stuart A.\} and Young, \{Daniel W.\} and Shirley Cosby and Crystal Helms and Teresita Angtuaco and \{Carol Sikes\}, N. and Mason, \{Melanie J.\} and \{Whit Hall\}, R. and Cohen, \{Harris L.\} and \{Gene targets for IVH study group\} and \{Neonatal research network genomics study group\}",

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T1 - Genes and environment in neonatal intraventricular hemorrhage

AU - Ment, Laura R.

AU - Ådén, Ulrika

AU - Bauer, Charles R.

AU - Bada, Henrietta S.

AU - Carlo, Waldemar A.

AU - Kaiser, Jeffrey R.

AU - Lin, Aiping

AU - Cotten, Charles Michael

AU - Murray, Jeffrey

AU - Page, Grier

AU - Hallman, Mikko

AU - Lifton, Richard P.

AU - Zhang, Heping

AU - Bryant, Cindy

AU - Cassady, Christopher

AU - Garcia, Carmen

AU - Johnson, Yvette R.

AU - Karpen, Heidi E.

AU - Munden, Martha M.

AU - Shores, Geneva

AU - Cassese, John

AU - Hensman, Angelita M.

AU - Vieira, Elisa

AU - Vohr, Betty

AU - Wallach, Michael

AU - Cummings, James J.

AU - MacGilvray, Scott S.

AU - Moseley, Sherry

AU - Trapanotto, Vickie

AU - Poindexter, Brenda

AU - Wilson, Leslie Dawn

AU - Wright-Coltart, Shirley

AU - Bartocci, Marco

AU - Printz, Gordana

AU - Hopper, Andrew

AU - Smith, Leon

AU - Wood, Beverly P.

AU - Young, Lionel

AU - Allan, Walter C.

AU - Alfsson, Jessica

AU - Sävman, Karin

AU - Royal, Stuart A.

AU - Young, Daniel W.

AU - Cosby, Shirley

AU - Helms, Crystal

AU - Angtuaco, Teresita

AU - Carol Sikes, N.

AU - Mason, Melanie J.

AU - Whit Hall, R.

AU - Cohen, Harris L.

AU - Gene targets for IVH study group

AU - Neonatal research network genomics study group

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N2 - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

AB - Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.

KW - Genes

KW - GWAS

KW - Intraventricular hemorrhage

KW - Neonate

KW - Preterm

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DO - 10.1053/j.semperi.2015.09.006

M3 - Review article

C2 - 26516117

AN - SCOPUS:84946738462

SN - 0146-0005

VL - 39

SP - 592

EP - 603

JO - Seminars in Perinatology

JF - Seminars in Perinatology

IS - 8

ER -

Genes and environment in neonatal intraventricular hemorrhage

Abstract

Keywords

ASJC Scopus subject areas

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