Generalized intramuscular granulocytic sarcoma mimicking polymyositis

Jan Fritz; Wichard Vogel; Claus D. Claussen; Martin Wehrmann; Philippe L. Pereira; Marius S. Horger

doi:10.1007/s00256-007-0314-6

Generalized intramuscular granulocytic sarcoma mimicking polymyositis

Jan Fritz, Wichard Vogel, Claus D. Claussen, Martin Wehrmann, Philippe L. Pereira, Marius S. Horger

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We report a case of granulocytic sarcoma exclusively manifesting as diffuse intramuscular infiltration of the proximal upper and lower limb girdle and the torso muscles in a patient with previous history of acute myelogenous leukemia 5a. Whole-body CT showed widespread distribution of ill-defined intramuscular, homogeneously enhancing lesions. On whole-body MRI, lesions were homogeneously hyperintense on fat saturated T2-weighted images, isointense on T1-weighted images and strongly enhancing after intravenous gadolinium contrast administration. Histopathology revealed muscular infiltration of blast cells with identical immunochemistry to the initial manifestation of leukemia, diagnostic for an extramedullary relapse manifesting as granulocytic sarcoma. CT and MRI characteristics of this previously undocumented manifestation of granulocytic sarcoma should assist in the identification of such cases.

Original language	English (US)
Pages (from-to)	985-989
Number of pages	5
Journal	Skeletal Radiology
Volume	36
Issue number	10
DOIs	https://doi.org/10.1007/s00256-007-0314-6
State	Published - Oct 2007
Externally published	Yes

Keywords

CT
Chloroma
Granulocytic sarcoma
MRI
Myelogenous leukemia

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s00256-007-0314-6

Cite this

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title = "Generalized intramuscular granulocytic sarcoma mimicking polymyositis",

abstract = "We report a case of granulocytic sarcoma exclusively manifesting as diffuse intramuscular infiltration of the proximal upper and lower limb girdle and the torso muscles in a patient with previous history of acute myelogenous leukemia 5a. Whole-body CT showed widespread distribution of ill-defined intramuscular, homogeneously enhancing lesions. On whole-body MRI, lesions were homogeneously hyperintense on fat saturated T2-weighted images, isointense on T1-weighted images and strongly enhancing after intravenous gadolinium contrast administration. Histopathology revealed muscular infiltration of blast cells with identical immunochemistry to the initial manifestation of leukemia, diagnostic for an extramedullary relapse manifesting as granulocytic sarcoma. CT and MRI characteristics of this previously undocumented manifestation of granulocytic sarcoma should assist in the identification of such cases.",

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T1 - Generalized intramuscular granulocytic sarcoma mimicking polymyositis

AU - Fritz, Jan

AU - Vogel, Wichard

AU - Claussen, Claus D.

AU - Wehrmann, Martin

AU - Pereira, Philippe L.

AU - Horger, Marius S.

PY - 2007/10

Y1 - 2007/10

N2 - We report a case of granulocytic sarcoma exclusively manifesting as diffuse intramuscular infiltration of the proximal upper and lower limb girdle and the torso muscles in a patient with previous history of acute myelogenous leukemia 5a. Whole-body CT showed widespread distribution of ill-defined intramuscular, homogeneously enhancing lesions. On whole-body MRI, lesions were homogeneously hyperintense on fat saturated T2-weighted images, isointense on T1-weighted images and strongly enhancing after intravenous gadolinium contrast administration. Histopathology revealed muscular infiltration of blast cells with identical immunochemistry to the initial manifestation of leukemia, diagnostic for an extramedullary relapse manifesting as granulocytic sarcoma. CT and MRI characteristics of this previously undocumented manifestation of granulocytic sarcoma should assist in the identification of such cases.

AB - We report a case of granulocytic sarcoma exclusively manifesting as diffuse intramuscular infiltration of the proximal upper and lower limb girdle and the torso muscles in a patient with previous history of acute myelogenous leukemia 5a. Whole-body CT showed widespread distribution of ill-defined intramuscular, homogeneously enhancing lesions. On whole-body MRI, lesions were homogeneously hyperintense on fat saturated T2-weighted images, isointense on T1-weighted images and strongly enhancing after intravenous gadolinium contrast administration. Histopathology revealed muscular infiltration of blast cells with identical immunochemistry to the initial manifestation of leukemia, diagnostic for an extramedullary relapse manifesting as granulocytic sarcoma. CT and MRI characteristics of this previously undocumented manifestation of granulocytic sarcoma should assist in the identification of such cases.

KW - CT

KW - Chloroma

KW - Granulocytic sarcoma

KW - MRI

KW - Myelogenous leukemia

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Generalized intramuscular granulocytic sarcoma mimicking polymyositis

Abstract

Keywords

ASJC Scopus subject areas

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