General personality dimensions, impairment and treatment response in obsessive–compulsive disorder

Jack Samuels, O. Joseph Bienvenu, Janice Krasnow, Ying Wang, Marco A. Grados, Bernadette Cullen, Fernando S. Goes, Brion Maher, Benjamin D. Greenberg, Nicole C. Mclaughlin, Steven A. Rasmussen, Abby J. Fyer, James A. Knowles, James T. Mccracken, John Piacentini, Dan Geller, S. Evelyn Stewart, Dennis L. Murphy, Yin Yao Shugart, Mark A. RiddleGerald Nestadt

Research output: Contribution to journalArticlepeer-review


General personality dimensions are associated with clinical severity and treatment response in individuals with depression and many anxiety disorders, but little is known about these relationships in individuals with obsessive–compulsive disorder (OCD). Individuals in the current study included 705 adults with OCD who had participated in family and genetic studies of the disorder. Participants self-completed the Neuroticism, Extraversion, Openness Personality Inventory or Neuroticism, Extraversion, Openness Five-Factor Inventory-3. Relationships between personality scores, and subjective impairment and OCD treatment response, were evaluated. The odds of subjective impairment increased with (unit increase in) the neuroticism score (odds ratio, OR = 1.03; 95% CI = 1.01–1.04; p < 0.01) and decreased with extraversion scores (OR = 0.98; 95% CI = 0.96–0.99; p < 0.01). The odds of reporting a good response to serotonin/selective serotonin reuptake inhibitors (OR = 1.02; 95% CI = 1.01–1.04; p < 0.01) or cognitive behavioural therapy (OR = 1.03; 95% CI = 1.01–1.05; p < 0.01) increased with the extraversion score. The magnitude of these relationships did not change appreciably after adjusting for other clinical features related to one or more of the personality dimensions. The findings suggest that neuroticism and extraversion are associated with subjective impairment, and that extraversion is associated with self-reported treatment response, in individuals with OCD.

Original languageEnglish (US)
Pages (from-to)186-198
Number of pages13
JournalPersonality and Mental Health
Issue number2
StatePublished - May 1 2020

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Health Policy
  • Psychiatry and Mental health


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