Gene therapy in peripheral artery disease

G. Melillo, F. Serino, C. Cirielli, M. C. Capogrossi

Research output: Contribution to journalReview articlepeer-review


In the last decade, studies of the biological mechanisms underlying angiogenesis, i.e. the development of a new vasculature from pre-existing blood vessels, have suggested a new approach to peripheral obstructive artery disease based on the treatment of ischemic tissues with angiogenic growth factors. As demonstrated by experimental studies in animal models, a therapeutic effect can be reached as the newly formed vascular network, functioning as a biologic by-pass, restores a normal blood supply to the ischemic territories. New techniques of gene therapy proved effective in reaching sustained concentrations of angiogenic factors in the target tissues. This review concerns the pre-clinical background and the results of the early clinical trials of angiogenic gene therapy, which have shown the safety and feasibility of this new approach.

Original languageEnglish (US)
Pages (from-to)295-300
Number of pages6
JournalCurrent Drug Targets - Cardiovascular and Haematological Disorders
Issue number3
StatePublished - Sep 2004
Externally publishedYes


  • Angiogenesis
  • Clinical trial
  • Gene therapy
  • Growth factors
  • Peripheral arterial obstructive disease

ASJC Scopus subject areas

  • Molecular Medicine
  • Hematology
  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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