Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

Josh G. Chenoweth; Carlo Colantuoni; Deborah A. Striegel; Pavol Genzor; Joost Brandsma; Paul W. Blair; Subramaniam Krishnan; Elizabeth Chiyka; Mehran Fazli; Rittal Mehta; Michael Considine; Leslie Cope; Audrey C. Knight; Anissa Elayadi; Anne Fox; Ronna Hertzano; Andrew G. Letizia; Alex Owusu-Ofori; Isaac Boakye; Albert A. Aduboffour; Daniel Ansong; Eno Biney; George Oduro; Kevin L. Schully; Danielle V. Clark

doi:10.1038/s41467-024-48821-0

Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

Josh G. Chenoweth, Carlo Colantuoni, Deborah A. Striegel, Pavol Genzor, Joost Brandsma, Paul W. Blair, Subramaniam Krishnan, Elizabeth Chiyka, Mehran Fazli, Rittal Mehta, Michael Considine, Leslie Cope, Audrey C. Knight, Anissa Elayadi, Anne Fox, Ronna Hertzano, Andrew G. Letizia, Alex Owusu-Ofori, Isaac Boakye, Albert A. AduboffourDaniel Ansong, Eno Biney, George Oduro, Kevin L. Schully, Danielle V. Clark

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis burden is increased which inhibits generalized strategies for therapeutic intervention. Here we perform RNA sequencing of whole blood to investigate longitudinal host response to sepsis in a Ghanaian cohort. Data dimensional reduction reveals dynamic gene expression patterns that describe cell type-specific molecular phenotypes including a dysregulated myeloid compartment shared between sepsis and COVID-19. The gene expression signatures reported here define a landscape of host response to sepsis that supports interventions via targeting immunophenotypes to improve outcomes.

Original language	English (US)
Article number	4606
Journal	Nature communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-48821-0
State	Published - Dec 2024

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-024-48821-0

Cite this

Chenoweth, J. G., Colantuoni, C., Striegel, D. A., Genzor, P., Brandsma, J., Blair, P. W., Krishnan, S., Chiyka, E., Fazli, M., Mehta, R., Considine, M., Cope, L., Knight, A. C., Elayadi, A., Fox, A., Hertzano, R., Letizia, A. G., Owusu-Ofori, A., Boakye, I., ... Clark, D. V. (2024). Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes. Nature communications, 15(1), Article 4606. https://doi.org/10.1038/s41467-024-48821-0

Chenoweth, JG, Colantuoni, C, Striegel, DA, Genzor, P, Brandsma, J, Blair, PW, Krishnan, S, Chiyka, E, Fazli, M, Mehta, R, Considine, M, Cope, L, Knight, AC, Elayadi, A, Fox, A, Hertzano, R, Letizia, AG, Owusu-Ofori, A, Boakye, I, Aduboffour, AA, Ansong, D, Biney, E, Oduro, G, Schully, KL & Clark, DV 2024, 'Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes', Nature communications, vol. 15, no. 1, 4606. https://doi.org/10.1038/s41467-024-48821-0

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abstract = "Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis burden is increased which inhibits generalized strategies for therapeutic intervention. Here we perform RNA sequencing of whole blood to investigate longitudinal host response to sepsis in a Ghanaian cohort. Data dimensional reduction reveals dynamic gene expression patterns that describe cell type-specific molecular phenotypes including a dysregulated myeloid compartment shared between sepsis and COVID-19. The gene expression signatures reported here define a landscape of host response to sepsis that supports interventions via targeting immunophenotypes to improve outcomes.",

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AU - Brandsma, Joost

AU - Blair, Paul W.

AU - Krishnan, Subramaniam

AU - Chiyka, Elizabeth

AU - Fazli, Mehran

AU - Mehta, Rittal

AU - Considine, Michael

AU - Cope, Leslie

AU - Knight, Audrey C.

AU - Elayadi, Anissa

AU - Fox, Anne

AU - Hertzano, Ronna

AU - Letizia, Andrew G.

AU - Owusu-Ofori, Alex

AU - Boakye, Isaac

AU - Aduboffour, Albert A.

AU - Ansong, Daniel

AU - Biney, Eno

AU - Oduro, George

AU - Schully, Kevin L.

AU - Clark, Danielle V.

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Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

Abstract

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