Gene-environment interaction between adiponectin gene polymorphisms and environmental factors on the risk of diabetic retinopathy

Yuan Li, Qun Hong Wu, Ming Li Jiao, Xiao Hong Fan, Quan Hu, Yan Hua Hao, Ruo Hong Liu, Wei Zhang, Yu Cui, Li Yuan Han

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Aims/Introduction: To evaluate whether the adiponectin gene is associated with diabetic retinopathy (DR) risk and interaction with environmental factors modifies the DR risk, and to investigate the relationship between serum adiponectin levels and DR. Materials and Methods: Four adiponectin polymorphisms were evaluated in 372 DR cases and 145 controls. Differences in environmental factors between cases and controls were evaluated by unconditional logistic regression analysis. The model-free multifactor dimensionality reduction method and traditional multiple regression models were applied to explore interactions between the polymorphisms and environmental factors. Results: Using the Bonferroni method, we found no significant associations between four adiponectin polymorphisms and DR susceptibility. Multivariate logistic regression found that physical activity played a protective role in the progress of DR, whereas family history of diabetes (odds ratio 1.75) and insulin therapy (odds ratio 1.78) were associated with an increased risk for DR. The interaction between the C-11377 G (rs266729) polymorphism and insulin therapy might be associated with DR risk. Family history of diabetes combined with insulin therapy also increased the risk of DR. No adiponectin gene polymorphisms influenced the serum adiponectin levels. Serum adiponectin levels did not differ between the DR group and non-DR group. Conclusions: No significant association was identified between four adiponectin polymorphisms and DR susceptibility after stringent Bonferroni correction. The interaction between C-11377G (rs266729) polymorphism and insulin therapy, as well as the interaction between family history of diabetes and insulin therapy, might be associated with DR susceptibility.

Original languageEnglish (US)
Pages (from-to)56-66
Number of pages11
JournalJournal of Diabetes Investigation
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes


  • Adiponectin
  • Diabetic retinopathy
  • Gene-environment interaction

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine


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