Gender specificity of altered human immune cytokine profiles in aging

Edward J. Goetzl, Mei Chuan Huang, Junko Kon, Kalpesh Patel, Janice B. Schwartz, Katharine Fast, Luigi Ferrucci, Karen Madara, Dennis D. Taub, Dan L. Longo

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Cytokine generation by T cells and monocytes was determined for 50 subjects aged 65 yr or older and concurrently studied young subjects individually matched to each old subject for sex, race, and national origin. Highly significant differences between cytokine levels of old and young subjects all were gender specific. For T cells stimulated with anti-CD3 plus anti-CD28 antibodies, mean ratios of IFN-γ generation for healthy old to young subjects were 0.22 for men (P

Original languageEnglish (US)
Pages (from-to)3580-3589
Number of pages10
JournalFASEB Journal
Issue number9
StatePublished - Sep 2010
Externally publishedYes


  • Autoimmunity
  • Immunodeficiency
  • Monocytes
  • T cells

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Genetics
  • Molecular Biology


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