Gender specificity of altered human immune cytokine profiles in aging

Edward J. Goetzl; Mei Chuan Huang; Junko Kon; Kalpesh Patel; Janice B. Schwartz; Katharine Fast; Luigi Ferrucci; Karen Madara; Dennis D. Taub; Dan L. Longo

doi:10.1096/fj.10-160911

Gender specificity of altered human immune cytokine profiles in aging

Edward J. Goetzl, Mei Chuan Huang, Junko Kon, Kalpesh Patel, Janice B. Schwartz, Katharine Fast, Luigi Ferrucci, Karen Madara, Dennis D. Taub, Dan L. Longo

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Cytokine generation by T cells and monocytes was determined for 50 subjects aged 65 yr or older and concurrently studied young subjects individually matched to each old subject for sex, race, and national origin. Highly significant differences between cytokine levels of old and young subjects all were gender specific. For T cells stimulated with anti-CD3 plus anti-CD28 antibodies, mean ratios of IFN-γ generation for healthy old to young subjects were 0.22 for men (P

Original language	English (US)
Pages (from-to)	3580-3589
Number of pages	10
Journal	FASEB Journal
Volume	24
Issue number	9
DOIs	https://doi.org/10.1096/fj.10-160911
State	Published - Sep 2010
Externally published	Yes

Keywords

Autoimmunity
Immunodeficiency
Monocytes
T cells

ASJC Scopus subject areas

Biochemistry
Biotechnology
Genetics
Molecular Biology

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10.1096/fj.10-160911

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AU - Goetzl, Edward J.

AU - Huang, Mei Chuan

AU - Kon, Junko

AU - Patel, Kalpesh

AU - Schwartz, Janice B.

AU - Fast, Katharine

AU - Ferrucci, Luigi

AU - Madara, Karen

AU - Taub, Dennis D.

AU - Longo, Dan L.

PY - 2010/9

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N2 - Cytokine generation by T cells and monocytes was determined for 50 subjects aged 65 yr or older and concurrently studied young subjects individually matched to each old subject for sex, race, and national origin. Highly significant differences between cytokine levels of old and young subjects all were gender specific. For T cells stimulated with anti-CD3 plus anti-CD28 antibodies, mean ratios of IFN-γ generation for healthy old to young subjects were 0.22 for men (P

AB - Cytokine generation by T cells and monocytes was determined for 50 subjects aged 65 yr or older and concurrently studied young subjects individually matched to each old subject for sex, race, and national origin. Highly significant differences between cytokine levels of old and young subjects all were gender specific. For T cells stimulated with anti-CD3 plus anti-CD28 antibodies, mean ratios of IFN-γ generation for healthy old to young subjects were 0.22 for men (P

KW - Autoimmunity

KW - Immunodeficiency

KW - Monocytes

KW - T cells

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Gender specificity of altered human immune cytokine profiles in aging

Abstract

Keywords

ASJC Scopus subject areas

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