Gender influences sphincter of Oddi response to cholecystokinin in the prairie dog

S. Tierney, Z. Qian, B. Yung, P. A. Lipsett, H. A. Pitt, S. Sostre, K. D. Lillemoe

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Although gallstones and disorders of biliary tract motility are both more common in women than men, sphincter of Oddi motility has not previously been compared between the sexes. In this study, cholescintigraphy (under ketamine and diazepam anesthesia) was used to determine gallbladder emptying rate and ejection fraction in response to cholecystokinin (CCK) in eight male and six female prairie dogs fed a nonlithogenic diet. Ten days later, under α- chloralose anesthesia, sphincter of Oddi phasic wave activity was monitored for 10-min intervals before (control), during 20 min of CCK infusion, and for 20 min after infusion. Gallbladder emptying rate and ejection fraction and baseline sphincter of Oddi frequency, amplitude, and motility index (= frequency x amplitude) did not differ significantly between the sexes. Sphincter of Oddi phasic wave frequency was increased during CCK infusion in both males and females, but the change in amplitude was significantly greater in females than males. We conclude that the increased incidence of biliary tract disease in women may be due to altered sphincter of Oddi hormonal response.

Original languageEnglish (US)
Pages (from-to)G476-G480
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number4 32-4
StatePublished - Jan 1 1995


  • cholelithiasis
  • cholescintigraphy

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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