Gender affirming hormone therapy dosing behaviors among transgender and nonbinary adults

Arjee Restar; E. J. Dusic; Henri Garrison-Desany; Elle Lett; Avery Everhart; Kellan E. Baker; Ayden I. Scheim; S. Wilson Beckham; Sari Reisner; Adam J. Rose; Matthew J. Mimiaga; Asa Radix; Don Operario; Jackie Hughto

doi:10.1057/s41599-022-01291-5

Gender affirming hormone therapy dosing behaviors among transgender and nonbinary adults

Arjee Restar, E. J. Dusic, Henri Garrison-Desany, Elle Lett, Avery Everhart, Kellan E. Baker, Ayden I. Scheim, S. Wilson Beckham, Sari Reisner, Adam J. Rose, Matthew J. Mimiaga, Asa Radix, Don Operario, Jackie Hughto

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Gender-affirming hormones have been shown to improve psychological functioning and quality of life among transgender and nonbinary (trans) people, yet, scant research exists regarding whether and why individuals take more or less hormones than prescribed. Drawing on survey data from 379 trans people who were prescribed hormones, we utilized multivariable logistic regression models to identify factors associated with hormone-dosing behaviors and content analysis to examine the reasons for dose modifications. Overall, 24% of trans individuals took more hormones than prescribed and 57% took less. Taking more hormones than prescribed was significantly associated with having the same provider for primary and gender-affirming care and gender-based discrimination. Income and insurance coverage barriers were significantly associated with taking less hormones than prescribed. Differences by gender identity were also observed. Addressing barriers to hormone access and cost could help to ensure safe hormone-dosing behaviors and the achievement trans people’s gender-affirmation goals.

Original language	English (US)
Article number	304
Journal	Humanities and Social Sciences Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1057/s41599-022-01291-5
State	Published - Dec 2022

ASJC Scopus subject areas

General Arts and Humanities
General Social Sciences
General Psychology
Economics, Econometrics and Finance(all)
General Business, Management and Accounting

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10.1057/s41599-022-01291-5

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Restar, A., Dusic, E. J., Garrison-Desany, H., Lett, E., Everhart, A., Baker, K. E., Scheim, A. I., Beckham, S. W., Reisner, S., Rose, A. J., Mimiaga, M. J., Radix, A., Operario, D., & Hughto, J. (2022). Gender affirming hormone therapy dosing behaviors among transgender and nonbinary adults. Humanities and Social Sciences Communications, 9(1), Article 304. https://doi.org/10.1057/s41599-022-01291-5

Restar, A, Dusic, EJ, Garrison-Desany, H, Lett, E, Everhart, A, Baker, KE, Scheim, AI, Beckham, SW, Reisner, S, Rose, AJ, Mimiaga, MJ, Radix, A, Operario, D & Hughto, J 2022, 'Gender affirming hormone therapy dosing behaviors among transgender and nonbinary adults', Humanities and Social Sciences Communications, vol. 9, no. 1, 304. https://doi.org/10.1057/s41599-022-01291-5

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abstract = "Gender-affirming hormones have been shown to improve psychological functioning and quality of life among transgender and nonbinary (trans) people, yet, scant research exists regarding whether and why individuals take more or less hormones than prescribed. Drawing on survey data from 379 trans people who were prescribed hormones, we utilized multivariable logistic regression models to identify factors associated with hormone-dosing behaviors and content analysis to examine the reasons for dose modifications. Overall, 24% of trans individuals took more hormones than prescribed and 57% took less. Taking more hormones than prescribed was significantly associated with having the same provider for primary and gender-affirming care and gender-based discrimination. Income and insurance coverage barriers were significantly associated with taking less hormones than prescribed. Differences by gender identity were also observed. Addressing barriers to hormone access and cost could help to ensure safe hormone-dosing behaviors and the achievement trans people{\textquoteright}s gender-affirmation goals.",

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note = "Funding Information: We would like to thank the participants of this study, and our research members for their assistance with this study: Jackson McMahon, Christopher Santostefano, David Pletta, and Ryan Segur. This work is supported by the Providence/Boston Center for AIDS Research (CFAR) funded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under grant number P30AI042853. Dr. Restar is supported by the Robert Wood Johnson Foundation Health Policy Research Scholar. Drs. Restar and Radix are supported by the Yale School of Public Health{\textquoteright}s Research Education Institute for Diverse Scholars (REIDS), funded by the National Institute of Mental Health (R25MH087217). The views and opinions expressed in this article are solely those of the authors and do not necessarily represent the official views of the sponsors. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

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N2 - Gender-affirming hormones have been shown to improve psychological functioning and quality of life among transgender and nonbinary (trans) people, yet, scant research exists regarding whether and why individuals take more or less hormones than prescribed. Drawing on survey data from 379 trans people who were prescribed hormones, we utilized multivariable logistic regression models to identify factors associated with hormone-dosing behaviors and content analysis to examine the reasons for dose modifications. Overall, 24% of trans individuals took more hormones than prescribed and 57% took less. Taking more hormones than prescribed was significantly associated with having the same provider for primary and gender-affirming care and gender-based discrimination. Income and insurance coverage barriers were significantly associated with taking less hormones than prescribed. Differences by gender identity were also observed. Addressing barriers to hormone access and cost could help to ensure safe hormone-dosing behaviors and the achievement trans people’s gender-affirmation goals.

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Gender affirming hormone therapy dosing behaviors among transgender and nonbinary adults

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