GCPII imaging and cancer

C. A. Foss; R. C. Mease; S. Y. Cho; H. J. Kim; M. G. Pomper

doi:10.2174/092986712799462612

GCPII imaging and cancer

C. A. Foss, R. C. Mease, S. Y. Cho, H. J. Kim, M. G. Pomper

School of Medicine

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Glutamate carboxypeptidase II (GCPII) in the central nervous system is referred to as the prostate-specific membrane antigen (PSMA) in the periphery. PSMA serves as a target for imaging and treatment of prostate cancer and because of its expression in solid tumor neovasculature has the potential to be used in this regard for other malignancies as well. An overview of GCPII/PSMA in cancer, as well as a discussion of imaging and therapy of prostate cancer using a wide variety of PSMA-targeting agents is provided.

Original language	English (US)
Pages (from-to)	1346-1359
Number of pages	14
Journal	Current medicinal chemistry
Volume	19
Issue number	9
DOIs	https://doi.org/10.2174/092986712799462612
State	Published - Mar 2012

Keywords

PET
PSMA
Prostate-specific membrane antigen
SPECT
molecular imaging
prostate cancer

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Organic Chemistry

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10.2174/092986712799462612

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title = "GCPII imaging and cancer",

abstract = "Glutamate carboxypeptidase II (GCPII) in the central nervous system is referred to as the prostate-specific membrane antigen (PSMA) in the periphery. PSMA serves as a target for imaging and treatment of prostate cancer and because of its expression in solid tumor neovasculature has the potential to be used in this regard for other malignancies as well. An overview of GCPII/PSMA in cancer, as well as a discussion of imaging and therapy of prostate cancer using a wide variety of PSMA-targeting agents is provided.",

keywords = "PET, PSMA, Prostate-specific membrane antigen, SPECT, molecular imaging, prostate cancer",

author = "Foss, {C. A.} and Mease, {R. C.} and Cho, {S. Y.} and Kim, {H. J.} and Pomper, {M. G.}",

year = "2012",

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doi = "10.2174/092986712799462612",

language = "English (US)",

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journal = "Current medicinal chemistry",

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T1 - GCPII imaging and cancer

AU - Foss, C. A.

AU - Mease, R. C.

AU - Cho, S. Y.

AU - Kim, H. J.

AU - Pomper, M. G.

PY - 2012/3

Y1 - 2012/3

N2 - Glutamate carboxypeptidase II (GCPII) in the central nervous system is referred to as the prostate-specific membrane antigen (PSMA) in the periphery. PSMA serves as a target for imaging and treatment of prostate cancer and because of its expression in solid tumor neovasculature has the potential to be used in this regard for other malignancies as well. An overview of GCPII/PSMA in cancer, as well as a discussion of imaging and therapy of prostate cancer using a wide variety of PSMA-targeting agents is provided.

AB - Glutamate carboxypeptidase II (GCPII) in the central nervous system is referred to as the prostate-specific membrane antigen (PSMA) in the periphery. PSMA serves as a target for imaging and treatment of prostate cancer and because of its expression in solid tumor neovasculature has the potential to be used in this regard for other malignancies as well. An overview of GCPII/PSMA in cancer, as well as a discussion of imaging and therapy of prostate cancer using a wide variety of PSMA-targeting agents is provided.

KW - PET

KW - PSMA

KW - Prostate-specific membrane antigen

KW - SPECT

KW - molecular imaging

KW - prostate cancer

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JO - Current medicinal chemistry

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GCPII imaging and cancer

Abstract

Keywords

ASJC Scopus subject areas

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