GATA-3 as a Marker of Hormone Response in Breast Cancer

Sandy H. Fang, Yizhen Chen, Ronald J. Weigel

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


GATA-3 is a transcription factor that orchestrates gene expression profiles during embryogenesis of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 has recently been identified as a key player of luminal cell differentiation in the mammary gland. The majority of breast cancers arise from luminal epithelial cells and hence GATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with the expression of estrogen receptor-α (ER) in breast cancer, and there is mounting evidence that GATA-3 can be used as a clinical marker to determine response to hormonal therapy and to refine the prognosis of breast cancer patients. Here, we review the literature from the past 10 y on GATA-3 in normal and pathological states of the mammary gland. Conclusions from the literature are confirmed using meta-analyses performed by the Oncomine Research Platform.

Original languageEnglish (US)
Pages (from-to)290-295
Number of pages6
JournalJournal of Surgical Research
Issue number2
StatePublished - Dec 2009
Externally publishedYes


  • GATA-3
  • breast cancer
  • estrogen receptor
  • hormone response

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'GATA-3 as a Marker of Hormone Response in Breast Cancer'. Together they form a unique fingerprint.

Cite this