Abstract
GATA-3 is a transcription factor that orchestrates gene expression profiles during embryogenesis of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 has recently been identified as a key player of luminal cell differentiation in the mammary gland. The majority of breast cancers arise from luminal epithelial cells and hence GATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with the expression of estrogen receptor-α (ER) in breast cancer, and there is mounting evidence that GATA-3 can be used as a clinical marker to determine response to hormonal therapy and to refine the prognosis of breast cancer patients. Here, we review the literature from the past 10 y on GATA-3 in normal and pathological states of the mammary gland. Conclusions from the literature are confirmed using meta-analyses performed by the Oncomine Research Platform.
Original language | English (US) |
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Pages (from-to) | 290-295 |
Number of pages | 6 |
Journal | Journal of Surgical Research |
Volume | 157 |
Issue number | 2 |
DOIs | |
State | Published - Dec 2009 |
Externally published | Yes |
Keywords
- GATA-3
- breast cancer
- estrogen receptor
- hormone response
ASJC Scopus subject areas
- Surgery