Gastrointestinal toxicity of cis-diamminedichloroplatinum (II). Personal observations

J. B. Vermorken, H. M. Pinedo

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51 Scopus citations


Gastrointestinal toxicity was studied in 45 patients receiving 207 cycles of cis-diamminedichloroplatinum(II) (cisplatin). Thirty-one patients received cisplatin in single doses. In this group of patients the drug was given either by rapid infusion or by 2-hour or 3-hour infusion or by 24-hour infusion in doses of 50 mg/m2 or less, 70-90 mg/m2 or 100 mg/m2. In 26 of the 31 patients the drug was used as a single agent. Fourteen additional patients received a daily dose of cisplatin of 20 mg/m2 for five consecutive days. All patients in this group were given combination chemotherapy. With cisplatin alone, single small doses (≤ 50 mg/m2) induced less nausea and vomiting than single doses of 70 mg/m2 or more (p2 and in 7 per cent of those treated with 90 mm/mg2 or less. Slight and transient increases in transaminases were observed more often with the single large dose schedule (100 mg/m2) than with the single small dose schedule or the daily x5 regimen (p <0.05). In single small dose treatment these increases were observed in 4 out of 6 patients receiving a rapid infusion, in 1 out of 7 patients with a 2-hour or 3-hour infusion and in 1 out of 8 patients with a 24-hour infusion. The pattern of increase of serum amylase in 4 patients was similar to that found for transaminases.

Original languageEnglish (US)
Pages (from-to)270-274
Number of pages5
JournalNetherlands Journal of Medicine
Issue number8
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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