Obesity or overweight is arguably the most obvious physical feature of PWS. Perhaps for this reason, more than 80% of the over 1,600 publications to date regarding PWS mention, discuss, and/or explore the topic of obesity. Despite this attention, the diagnosis, pathogenesis, optimal treatment, monitoring, and outcome of this condition in PWS remain undefi ned. In addition, the paradox of the underweight infant with PWS evolving into an overweight child and adult has led to considerable speculation regarding pathophysiology. In addition to the obvious physical feature of obesity/overweight and questions regarding optimal nutritional management, a variety of gastrointestinal (GI) disorders have been identifi ed in PWS, with frequencies similar to respiratory disorders. A description of the GI system and related disorders in PWS will start this chapter, followed by a discussion of obesity and related nutrition and medical issues. Finally, a discussion of analytical methods for body composition analysis and their application in PWS is presented (see Chapter 5 for a complete outline of Part II).
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