@article{e30e058fd8ef43dd86efc628fab922d9,
title = "Gastrointestinal dysfunction and disaccharide intolerance in children infected with human immunodeficiency virus",
abstract = "Because gastrointestinal dysfunction is a major problem in children with human immunodeficiency virus (HIV) infection, we utilized breath hydrogen measurements to determine the relationship between disaccharide malabsorption and gastrointestinal dysfunction in HIV-infected children. We found a strong association between lactose intolerance and persistent diarrheal disease in this population (p<0.007, Mann-Whitney U test). We also found evidence of sucrose malabsorption and persistent diarrheal disease in three of the children. Extensive microbiologic evaluations failed to reveal an etiologic agent related to the occurrence of gastrointestinal symptoms. Our findings indicate that disaccharide intolerance is a common occurrence in HIV-infected children with persistent diarrheal disease. Careful attention to dietary intake may be required to ameliorate clinical symptoms and to maintain adequate nutrition.",
author = "Yolken, {R. H.} and W. Hart and I. Oung and C. Shiff and J. Greenson and Perman, {J. A.}",
note = "Funding Information: Human immunodeficiency virus replicates in the lymphocytes and macrophages of infected persons; many of the clinical manifestations of HIV infection are due to immune cell dysfunction and subsequent immunodeficiency. 1 However, it is being increasingly recognized that HIV infection results in a multisystem disorder and that dysfunction of other organ systems can contribute to the disease state. 2 One such organ system is the gastrointestinal tract. Acute and chronic diarrhea, weight loss, abdominal pain, esophagitis, and other gastrointestinal symptoms have been noted in a substantial portion of adults with HIV infection. 35 In adults these symptoms are often, but not invariably, Supported by grant R01-DK-40540 from the National Institutes of Health. Submitted for publication Aug. 24, 1990; accepted Oct. 1, 1990. Reprint requests: Robert H. Y01ken, MD, Pediatric Infectious Diseases, CMSC 1109, Johns Hopkins Hospital, Baltimore, MD 21205. 9/20/25781 associated with infections with gastrointestinal pathogens such as Cryptosporidium, Giardia lamblia, Mycobacte-riurn avium-intracellulare, cytomegalovirus, and other agents.6, 7 Gastrointestinal dysfunction can predispose infants and young children to electrolyte imbalance and malnutrition, which may further exacerbate the T cell defects associated with HIV replication. 8, 9 Furthermore, the reli-",
year = "1991",
month = mar,
doi = "10.1016/S0022-3476(05)82147-X",
language = "English (US)",
volume = "118",
pages = "359--363",
journal = "The Journal of pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "3",
}