Gastroenteritis by rotavirus in Spanish children. Analysis of the disease burden

Francisco Javier Luquero Alcalde, José María Eiros Bouza, Alberto Pérez Rubio, Maria Rosario Bachiller Luque, José Javier Castrodeza Sanz, Raúl Ortiz De Lejarazu Leonardo

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Rotavirus is one of the most common causes of gastroenteritis worldwide. With the commercialisation of effective rotavirus vaccines in Europe in sight, it is necessary to provide studies which evaluate the disease burden. The aim of this study is two-fold, on one hand, to determine the burden of the rotavirus disease in Spanish children under the age of five, and on the other, to estimate the economic cost of these hospitalizations. The study was undertaken during a 5 year period (2000-2004). The rotavirus hospitalization rate was determined using the Minimum Basic Data Set of the national hospital discharge register. The observed data were compared with those expected by applying a model developed by the Centers for Disease Control and Prevention (CDC) adapted for European Countries. The financial expense of these hospitalizations was estimated. Of all admissions coded as gastroenteritis, 31.6% were due to rotavirus. The hospitalization rate by rotavirus was 480 cases per 100,000 children under five. These data are within the confidence range proposed by the adapted CDC model. The financial expense due to hospitalizations reaches 123,262 euros yearly in a Spanish University Hospital. In conclusion, rotavirus contributes significantly to the hospitalization of acute gastroenteritis. The rate of hospitalization by rotavirus is higher compared to other studies carried out in Spain. In view of future commercialisation of rotavirus vaccines, more in-depth analysis considering direct and indirect costs are necessary.

Original languageEnglish (US)
Pages (from-to)549-555
Number of pages7
JournalEuropean Journal of Pediatrics
Issue number5
StatePublished - May 2008
Externally publishedYes


  • Disease burden
  • Hospitalisation
  • Rotavirus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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