Gastric mesenchymal lesions other than gastrointestinal stromal tumor

Lysandra Voltaggio, Elizabeth Montgomery

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Interpretation of gastrointestinal mesenchymal lesions involving the stomach and the remainder of the gastrointestinal tract is daunting but can be simplified somewhat merely by knowing in which layer they are usually found. For example, gastric Kaposi sarcoma is detected in mucosal biopsies whereas inflammatory fibroid polyp is nearly always in the submucosa. Gastrointestinal stromal tumors (discussed elsewhere in this issue) are generally centered in the muscularis propria. Gastric schwannomas are essentially always in the muscularis propria. Mesenteric lesions are usually found in the small bowel mesentery but the gastric mesentery is not immune. Knowledge of the favored layer is even more important in interpreting colon biopsies, since many mesenschymal polyps are encountered in the colon, but the same principle applies in the stomach. Herein we discuss several gastric mesenchymal lesions.

Original languageEnglish (US)
Pages (from-to)228-238
Number of pages11
JournalDiagnostic Histopathology
Issue number6
StatePublished - Jun 2014


  • Gastric schwannoma
  • Gastrointestinal stromal tumor
  • Sarcoma mesenteric fibromatosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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