Gamma-guided stereotactic breast biopsy system

Benjamin Welch, Rachel Brem, Brian Kross, Vladimir Popov, Randy Wojcik, Stan Majewski

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


A gamma-ray imaging system has been developed for acquiring stereo images of the distribution of radiopharmaceuticals in breast tissue. The system consists of a small field-of-view gamma-ray camera mounted to a stereotactic biopsy table. The camera is mounted on a rotational arm such that it can be used to image the breast from two 15° stereo views. These stereo images can be used to determine the three dimensional spatial location of a region of focal uptake. Once the location of this region is determined, this information can be used as a guide for stereotactic core needle biopsy. The accuracy that the spatial location of a source can be determined was investigated by moving a point source within the field of view. A center-of gravity calculation was used to localize the centroid of the image of the source and this was used to determine the spatial location. Measurements indicate that the source can be localized to within 1 mm. A comparison of the operation of the gamma imaging system and an x-ray imaging system has been done using a dual modality phantom. These measurements indicated that the spatial location of an isolated source can be determined by the gamma imaging system to within approximately the same performance criteria as required for the X-ray system (1 mm). Collimators were tested to determine the spatial resolution in the transverse dimension and the impact of this transverse resolution on the axial resolution was investigated. The performance of this gamma-guided stereotactic biopsy system will be presented.

Original languageEnglish (US)
Article number1710257
Pages (from-to)2690-2697
Number of pages8
JournalIEEE Transactions on Nuclear Science
Issue number5
StatePublished - Oct 2006
Externally publishedYes


  • Biopsy
  • Breast cancer
  • Gamma camera
  • Stereotactic

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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