Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T 1 magnetic resonance imaging contrast agent

Zhiliang Cheng; Daniel L.J. Thorek; Andrew Tsourkas

doi:10.1002/anie.200905133

Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T ₁ magnetic resonance imaging contrast agent

Zhiliang Cheng
, Daniel L.J. Thorek
, Andrew Tsourkas

Research output: Contribution to journal › Article › peer-review

165 Scopus citations

Abstract

"Chemical Equation Presented" Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).

Original language	English (US)
Pages (from-to)	346-350
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	2
DOIs	https://doi.org/10.1002/anie.200905133
State	Published - Jan 8 2010
Externally published	Yes

Keywords

Dendrimers
Gadolinium
Imaging agents
Magnetic resonance imaging
Tumors

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.200905133

Cite this

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title = "Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T 1 magnetic resonance imaging contrast agent",

abstract = "{"}Chemical Equation Presented{"} Light heavyweight champion: Chemically cross-linked dendrimer nanoclusters (DNCs) have been developed as a platform for preparing targeted magnetic resonance contrast agents. The extremely high gadolinium payload causes the DNCs to show a significant improvement in tumor contrast compared with pre-contrast images (see picture).",

keywords = "Dendrimers, Gadolinium, Imaging agents, Magnetic resonance imaging, Tumors",

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AU - Tsourkas, Andrew

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KW - Dendrimers

KW - Gadolinium

KW - Imaging agents

KW - Magnetic resonance imaging

KW - Tumors

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