GABAergic dysfunction in pediatric neuro-developmental disorders

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed.

Original languageEnglish (US)
Article number269
JournalFrontiers in Cellular Neuroscience
Issue numberDEC
StatePublished - Dec 19 2013


  • Circuits
  • Critical period
  • Disease
  • PV interneurons
  • Synaptic plasticity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


Dive into the research topics of 'GABAergic dysfunction in pediatric neuro-developmental disorders'. Together they form a unique fingerprint.

Cite this