GABAergic dysfunction in pediatric neuro-developmental disorders

Constance L. Smith-Hicks

doi:10.3389/fncel.2013.00269

GABAergic dysfunction in pediatric neuro-developmental disorders

Constance L. Smith-Hicks

Kennedy Krieger Institute

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed.

Original language	English (US)
Article number	269
Journal	Frontiers in Cellular Neuroscience
Volume	7
Issue number	DEC
DOIs	https://doi.org/10.3389/fncel.2013.00269
State	Published - Dec 19 2013

Keywords

Circuits
Critical period
Disease
PV interneurons
Synaptic plasticity

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.3389/fncel.2013.00269

Cite this

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AB - The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed.

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KW - Disease

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KW - Synaptic plasticity

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GABAergic dysfunction in pediatric neuro-developmental disorders

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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