Further evidence that infection is an infrequent cause of first trimester spontaneous abortion

Joe Leigh Simpson, Ronald H. Gray, John T. Queenan, Michele Barbato, Alfredo Perez, Patricio Mena, Robert T. Kambic, Francisco Pardo, Wilma Stevenson, Chunjun Li, Victoria Jennings

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A previous cohort study found no clinical evidence that infection occurred more often in subjects experiencing pregnancy loss compared with those experiencing successful pregnancy. Given these surprising findings, we conducted a similar analysis on another cohort also followed prospectively. Using couples practising natural family planning for conception or contraception, information on clinical evidence of infection was gathered beginning with week 5 of gestation. Information on fever and signs of overt infection was specifically sought by interview and physical examination. Frequencies of urinary, vaginal and other infections in subjects experiencing pregnancy loss were 11.1, 9.5 and 8.7% respectively, not significantly different from rates in subjects having liveborns (10.1, 10.2 and 10.3% respectively). Thus, no association between clinical infection and early pregnancy loss (≤ 16 weeks) was observed. Cohort studies utilizing biologically based assays are awaited because extant data do not provide evidence that clinically evident infections play major roles in first trimester pregnancy losses.

Original languageEnglish (US)
Pages (from-to)2058-2060
Number of pages3
JournalHuman Reproduction
Issue number9
StatePublished - Sep 1996


  • First trimester
  • Infections
  • Spontaneous abortion

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


Dive into the research topics of 'Further evidence that infection is an infrequent cause of first trimester spontaneous abortion'. Together they form a unique fingerprint.

Cite this