Fungal lethality, binding, and cytotoxicity of syringomycin-E

A. J. De Lucca; T. J. Jacks; J. Takemoto; B. Vinyard; J. Peter; E. Navarro; T. J. Walsh

doi:10.1128/aac.43.2.371

Fungal lethality, binding, and cytotoxicity of syringomycin-E

A. J. De Lucca, T. J. Jacks, J. Takemoto, B. Vinyard, J. Peter, E. Navarro, T. J. Walsh

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 μg/ml. SE complexed with the following fungal wall constituents (in order of binding): β-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.

Original language	English (US)
Pages (from-to)	371-373
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	43
Issue number	2
DOIs	https://doi.org/10.1128/aac.43.2.371
State	Published - Feb 1999
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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AU - Navarro, E.

AU - Walsh, T. J.

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Fungal lethality, binding, and cytotoxicity of syringomycin-E

Abstract

ASJC Scopus subject areas

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