Fundus autofluorescence patterns in primary intraocular lymphoma

Megan Casady, Lisa Faia, Maryam Nazemzadeh, Robert Nussenblatt, Chi Chao Chan, H. Nida Sen

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


PURPOSE: To evaluate fundus autofluorescence (FAF) patterns in patients with primary intraocular (vitreoretinal) lymphoma. METHODS: Records of all patients with primary intraocular lymphoma who underwent FAF imaging at the National Eye Institute were reviewed. Fundus autofluorescence patterns were evaluated with respect to clinical disease status and the findings on fluorescein angiography and spectral-domain optical coherence tomography. RESULTS: There were 18 eyes (10 patients) with primary intraocular lymphoma that underwent FAF imaging. Abnormal autofluorescence in the form of granular hyperautofluorescence and hypoautofluorescence was seen in 11 eyes (61%), and blockage by mass lesion was seen in 2 eyes (11%). All eyes with granular pattern on FAF had active primary intraocular lymphoma at the time of imaging, but there were 5 eyes with unremarkable FAF, which were found to have active lymphoma. The most common pattern on fluorescein angiography was hypofluorescent round spots with a "leopard spot" appearance (43%). These hypofluorescent spots on fluorescein angiography correlated with hyperautofluorescent spots on FAF in 5 eyes (36%) (inversion of FAF). Nodular hyperreflective spots at the level of retinal pigment epithelium on optical coherence tomography were noted in 43% of eyes. The hyperautofluorescent spots on FAF correlated with nodular hyperreflective spots on optical coherence tomography in 6 eyes (43%). CONCLUSION: Granularity on FAF was associated with active lymphoma in majority of the cases. An inversion of FAF (hyperautofluorescent spots on FAF corresponding to hypofluorescent spots on fluorescein angiography) was observed in less than half of the eyes.

Original languageEnglish (US)
Pages (from-to)366-372
Number of pages7
Issue number2
StatePublished - Feb 2014
Externally publishedYes


  • Cytokines
  • Diagnosis
  • Fundus autofluorescence
  • Primary intraocular lymphoma
  • Primary vitreoretinal lymphoma
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology


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