@article{c81ecf3dfc4a40c886113b7b9c7ee82a,
title = "Funding for clinical trials",
abstract = "This paper provides a review of available funding sources for clinical trials, with emphasis on trials funded via the National Institutes of Health. Data from the NIH Inventory of Clinical Trials are used to summarize the cost and key design characteristics of NIH trials. The paper concludes with a discussion of some of the factors which add to the cost of trials.",
keywords = "clinical trials funding, expenditures, support",
author = "Meinert, {Curtis L.}",
note = "Funding Information: Patient Per Year Costs for NIH Extramural Grant vs. Contract Supported Trials Funding Information: Government grants and contracts Industry Foundations and public funds Academic research institutions Third-party sources It is quite conceivable that funds used by Medicare/Medicaid or Blue Cross/ Blue Shield, if used for support of trials designed to evaluate specific care procedures, could ultimately help reduce the outlay for ineffective or unnecessary procedures. The only detailed analysis I have been able to perform is for trials funded by the Veterans Administration (VA) and the National Institutes of Health (NIH). I say {"}only{"} because there are, to be sure, other agencies within the federal government that provide support for clinical trials but data on this is not readily available. VA expenditures for multicenter trials are recorded in Table 2 \[1\]T. he amount of support provided in 1981 for multicenter trials represents about 7% of the total VA research and development (R & D) budget. Table 3 provides expenditure data for NIH sponsored trials. These figures are based on data from the NIH Fact Book \[2\]a nd NIH Inventories of Clinical Trials for fiscal years 1975-79 \[3\]N. IH Inventories for 1980 and 1981 are not available. The inventory listings are based on data supplied by the various Institutes of the NIH. A clinical trial, as defined by the NIH, is A scientific research activity undertaken to define prospectively the effect and value of prophylactic/diagnostic/therapeutic agents, devices, regimens, procedures, etc., applied to human subjects. Funding Information: Table 5. Grant Supported Extramural NIH Trials Funding Information: Table 4 provides a breakdown of the 1979 cost figures by Institute, for all trials (NIH intramural as well as extramural) supported by the Heart (NHLBI), Cancer (NCI), and all other Institutes of the NIH. The median dollar cost per year of follow-up 1 is provided in the right-hand column of Table 4. The cost is highest for heart studies.",
year = "1982",
month = sep,
doi = "10.1016/0197-2456(82)90002-2",
language = "English (US)",
volume = "3",
pages = "165--171",
journal = "Controlled clinical trials",
issn = "0197-2456",
publisher = "Elsevier BV",
number = "3",
}