Functions and mechanisms of retrograde neurotrophin signalling

Larry S. Zweifel, Rejji Kuruvilla, David D. Ginty

Research output: Contribution to journalArticlepeer-review

325 Scopus citations


Neuronal connections are established and refined through a series of developmental programs that involve axon and dendrite specification, process growth, target innervation, cell death and synaptogenesis. Many of these developmental events are regulated by target-derived neurotrophins and their receptors, which signal retrogradely over long distances from distal-most axons to neuronal cell bodies. Recent work has established many of the cellular and molecular events that underlie retrograde signalling and the importance of these events for both development and maintenance of proper neural connectivity.

Original languageEnglish (US)
Pages (from-to)615-625
Number of pages11
JournalNature Reviews Neuroscience
Issue number8
StatePublished - Aug 2005
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cell Biology


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