Functional magnetic resonance cholangiography (fMRC) of the gallbladder and biliary tree with contrast-enhanced magnetic resonance cholangiography

Laura M. Fayad, George A. Holland, Diane Bergin, Nasir Iqbal, Laurence Parker, Paul G. Curcillo, Thomas E. Kowalski, Pauline Park, Charles Intenzo, Donald G. Mitchell

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


Purpose: To determine the diagnostic performance of functional magnetic resonance cholangiography (fMRC) for the evaluation of anatomic and functional biliary disorders. Materials and Methods: At 1.5 T, 39 MR examinations with conventional MRC and mangafodipir trisodium-enhanced fMRC were retrospectively reviewed by three observers who recorded anatomic (duct dilation, stricture, filling defects) and functional (cholecystitis, obstruction) abnormalities in three modes: MRC alone, FMRC alone, and MRC and fMRC images together (combined-MRC). Performance was determined by comparing findings with each mode to findings of invasive cholangiography (IC) and surgery. Results: Among 75 billary segments (correlated with IC), the sensitivity/specificity for diagnosing dilation (N = 41) with MRC was 95%/97%; with fMRC, 90%/100%; with combined-MRC, 100%/97%. For stricture (N = 7), the sensitivity/specificity of MRC was 86%/98%: of fMRC, 43%/100%; of combined-MRC, 86%/100%. For filling defects (N = 9), the sensitivity/specificity of MRC was 91%/98%; of fMRC 82%/ 100%; of combined-MRC, 91%/100%. For diagnosing obstruction (N = 9), the sensitivity/specificity of MRC, fMRC, and combined-MRC were 89%/100%, 100%/100%, and 100%/100%, respectively. For surgically proven cholecystitis (N = 13), positive predictive' values for diagnosing acute/ chronic cholecystitis for MRC were 33%/40%; for fMRC, 100%/50%; for combined-MRC, 100%/50%. Conclusion: Although single-shot fast spin echo (SSFSE)-MRC is valuable, the addition of fMRC-increased diagnostic performance for funtional biliary disorders.

Original languageEnglish (US)
Pages (from-to)449-460
Number of pages12
JournalJournal of Magnetic Resonance Imaging
Issue number4
StatePublished - Oct 1 2003


  • Bile duct abnormalities
  • Biliary obstruction
  • Cholecystitis
  • Contrast-enhanced magnetic resonance imaging
  • Magnetic resonance cholangiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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