Functional integration of microRNAs into oncogenic and tumor suppressor pathways

Craig D. Lotterman, Oliver A. Kent, Joshua T. Mendell

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


A large body of evidence has documented abnormal microRNA (miRNA) expression patterns in diverse human malignancies. Given that miRNA expression is tightly regulated during development and cellular differentiation, aberrant miRNA expression in cancer cells is likely to be in part a consequence of the loss of normal cellular identity that accompanies malignant transformation. Nevertheless, it is now clear that miRNAs function as critical effectors of several canonical oncogenic and tumor suppressor pathways, including those controlled by Myc and p53. Gain- and loss-of-function of these factors in cancer cells contributes to miRNA dysregulation, directly influencing neoplastic phenotypes including cellular proliferation and apoptosis.

Original languageEnglish (US)
Pages (from-to)2493-2499
Number of pages7
JournalCell Cycle
Issue number16
StatePublished - Aug 15 2008
Externally publishedYes


  • Fusion oncoprotein
  • Gene expression
  • Nuclear factorκB
  • Oncogene
  • Tumor suppressor
  • c-Myc
  • microRNA
  • p53

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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