Functional integration of microRNAs into oncogenic and tumor suppressor pathways

Craig D. Lotterman; Oliver A. Kent; Joshua T. Mendell

doi:10.4161/cc.7.16.6452

Functional integration of microRNAs into oncogenic and tumor suppressor pathways

Craig D. Lotterman, Oliver A. Kent, Joshua T. Mendell

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

A large body of evidence has documented abnormal microRNA (miRNA) expression patterns in diverse human malignancies. Given that miRNA expression is tightly regulated during development and cellular differentiation, aberrant miRNA expression in cancer cells is likely to be in part a consequence of the loss of normal cellular identity that accompanies malignant transformation. Nevertheless, it is now clear that miRNAs function as critical effectors of several canonical oncogenic and tumor suppressor pathways, including those controlled by Myc and p53. Gain- and loss-of-function of these factors in cancer cells contributes to miRNA dysregulation, directly influencing neoplastic phenotypes including cellular proliferation and apoptosis.

Original language	English (US)
Pages (from-to)	2493-2499
Number of pages	7
Journal	Cell Cycle
Volume	7
Issue number	16
DOIs	https://doi.org/10.4161/cc.7.16.6452
State	Published - Aug 15 2008
Externally published	Yes

Keywords

Fusion oncoprotein
Gene expression
Nuclear factorκB
Oncogene
Tumor suppressor
c-Myc
microRNA
p53

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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title = "Functional integration of microRNAs into oncogenic and tumor suppressor pathways",

abstract = "A large body of evidence has documented abnormal microRNA (miRNA) expression patterns in diverse human malignancies. Given that miRNA expression is tightly regulated during development and cellular differentiation, aberrant miRNA expression in cancer cells is likely to be in part a consequence of the loss of normal cellular identity that accompanies malignant transformation. Nevertheless, it is now clear that miRNAs function as critical effectors of several canonical oncogenic and tumor suppressor pathways, including those controlled by Myc and p53. Gain- and loss-of-function of these factors in cancer cells contributes to miRNA dysregulation, directly influencing neoplastic phenotypes including cellular proliferation and apoptosis.",

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AU - Kent, Oliver A.

AU - Mendell, Joshua T.

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N2 - A large body of evidence has documented abnormal microRNA (miRNA) expression patterns in diverse human malignancies. Given that miRNA expression is tightly regulated during development and cellular differentiation, aberrant miRNA expression in cancer cells is likely to be in part a consequence of the loss of normal cellular identity that accompanies malignant transformation. Nevertheless, it is now clear that miRNAs function as critical effectors of several canonical oncogenic and tumor suppressor pathways, including those controlled by Myc and p53. Gain- and loss-of-function of these factors in cancer cells contributes to miRNA dysregulation, directly influencing neoplastic phenotypes including cellular proliferation and apoptosis.

AB - A large body of evidence has documented abnormal microRNA (miRNA) expression patterns in diverse human malignancies. Given that miRNA expression is tightly regulated during development and cellular differentiation, aberrant miRNA expression in cancer cells is likely to be in part a consequence of the loss of normal cellular identity that accompanies malignant transformation. Nevertheless, it is now clear that miRNAs function as critical effectors of several canonical oncogenic and tumor suppressor pathways, including those controlled by Myc and p53. Gain- and loss-of-function of these factors in cancer cells contributes to miRNA dysregulation, directly influencing neoplastic phenotypes including cellular proliferation and apoptosis.

KW - Fusion oncoprotein

KW - Gene expression

KW - Nuclear factorκB

KW - Oncogene

KW - Tumor suppressor

KW - c-Myc

KW - microRNA

KW - p53

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Functional integration of microRNAs into oncogenic and tumor suppressor pathways

Abstract

Keywords

ASJC Scopus subject areas

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