Functional imaging of the vascular bed by dynamic optical tomography

Randall L. Barbour; Harry L. Graber; Yaling Pei; Christoph H. Schmitz; Yong Xu; Adriana Di Martino; F. Xavier Castellanos; David P. Klemer; Rosemarie E. Hardin; Nelson A. Franco; Michael S. Katz; Michael E. Zenilman; Alessandro G. Smeraldi; Thomas F. Panetta

doi:10.1117/12.537957

Functional imaging of the vascular bed by dynamic optical tomography

Randall L. Barbour, Harry L. Graber, Yaling Pei, Christoph H. Schmitz, Yong Xu, Adriana Di Martino, F. Xavier Castellanos, David P. Klemer, Rosemarie E. Hardin, Nelson A. Franco, Michael S. Katz, Michael E. Zenilman, Alessandro G. Smeraldi, Thomas F. Panetta

Research output: Contribution to journal › Conference article › peer-review

2 Scopus citations

Abstract

In this report we present a brief outline of our technological approaches to developing a comprehensive imaging platform suitable for the investigation of the dynamics of the hemoglobin signal in large tissue structures using NIRS imaging techniques. Our approach includes a combined hardware and software development effort that provides for i) hardware integration, ii) system calibration, iii) data integrity checks, iv) image recovery, v) image enhancement and vi) signal processing. Presented are representative results obtained from human subjects that explore the sensitivity and other capabilities of the measuring system to detect focal hemodynamic responses in the head, breast and limb of volunteers. Results obtained support the contention that time-series NIRS imaging is a powerful and sensitive technique for exploring the hemodynamics of healthy and diseased tissues.

Original language	English (US)
Pages (from-to)	132-149
Number of pages	18
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5369
DOIs	https://doi.org/10.1117/12.537957
State	Published - 2004
Externally published	Yes
Event	Medical Imaging 2004: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States Duration: Feb 15 2004 → Feb 17 2004

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.537957

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Barbour, R. L., Graber, H. L., Pei, Y., Schmitz, C. H., Xu, Y., Di Martino, A., Castellanos, F. X., Klemer, D. P., Hardin, R. E., Franco, N. A., Katz, M. S., Zenilman, M. E., Smeraldi, A. G., & Panetta, T. F. (2004). Functional imaging of the vascular bed by dynamic optical tomography. Proceedings of SPIE - The International Society for Optical Engineering, 5369, 132-149. https://doi.org/10.1117/12.537957

Barbour, RL, Graber, HL, Pei, Y, Schmitz, CH, Xu, Y, Di Martino, A, Castellanos, FX, Klemer, DP, Hardin, RE, Franco, NA, Katz, MS, Zenilman, ME, Smeraldi, AG & Panetta, TF 2004, 'Functional imaging of the vascular bed by dynamic optical tomography', Proceedings of SPIE - The International Society for Optical Engineering, vol. 5369, pp. 132-149. https://doi.org/10.1117/12.537957

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title = "Functional imaging of the vascular bed by dynamic optical tomography",

abstract = "In this report we present a brief outline of our technological approaches to developing a comprehensive imaging platform suitable for the investigation of the dynamics of the hemoglobin signal in large tissue structures using NIRS imaging techniques. Our approach includes a combined hardware and software development effort that provides for i) hardware integration, ii) system calibration, iii) data integrity checks, iv) image recovery, v) image enhancement and vi) signal processing. Presented are representative results obtained from human subjects that explore the sensitivity and other capabilities of the measuring system to detect focal hemodynamic responses in the head, breast and limb of volunteers. Results obtained support the contention that time-series NIRS imaging is a powerful and sensitive technique for exploring the hemodynamics of healthy and diseased tissues.",

author = "Barbour, {Randall L.} and Graber, {Harry L.} and Yaling Pei and Schmitz, {Christoph H.} and Yong Xu and {Di Martino}, Adriana and Castellanos, {F. Xavier} and Klemer, {David P.} and Hardin, {Rosemarie E.} and Franco, {Nelson A.} and Katz, {Michael S.} and Zenilman, {Michael E.} and Smeraldi, {Alessandro G.} and Panetta, {Thomas F.}",

year = "2004",

doi = "10.1117/12.537957",

language = "English (US)",

volume = "5369",

pages = "132--149",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

publisher = "SPIE",

note = "Medical Imaging 2004: Physiology, Function, and Structure from Medical Images ; Conference date: 15-02-2004 Through 17-02-2004",

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T1 - Functional imaging of the vascular bed by dynamic optical tomography

AU - Barbour, Randall L.

AU - Graber, Harry L.

AU - Pei, Yaling

AU - Schmitz, Christoph H.

AU - Xu, Yong

AU - Di Martino, Adriana

AU - Castellanos, F. Xavier

AU - Klemer, David P.

AU - Hardin, Rosemarie E.

AU - Franco, Nelson A.

AU - Katz, Michael S.

AU - Zenilman, Michael E.

AU - Smeraldi, Alessandro G.

AU - Panetta, Thomas F.

PY - 2004

Y1 - 2004

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AB - In this report we present a brief outline of our technological approaches to developing a comprehensive imaging platform suitable for the investigation of the dynamics of the hemoglobin signal in large tissue structures using NIRS imaging techniques. Our approach includes a combined hardware and software development effort that provides for i) hardware integration, ii) system calibration, iii) data integrity checks, iv) image recovery, v) image enhancement and vi) signal processing. Presented are representative results obtained from human subjects that explore the sensitivity and other capabilities of the measuring system to detect focal hemodynamic responses in the head, breast and limb of volunteers. Results obtained support the contention that time-series NIRS imaging is a powerful and sensitive technique for exploring the hemodynamics of healthy and diseased tissues.

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SP - 132

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JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Medical Imaging 2004: Physiology, Function, and Structure from Medical Images

Y2 - 15 February 2004 through 17 February 2004

ER -

Functional imaging of the vascular bed by dynamic optical tomography

Abstract

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