Functional Imaging of Cognitive Control During Acute Alcohol Intoxication

Beth M. Anderson; Michael C. Stevens; Shashwath A. Meda; Kathryn Jordan; Vince D. Calhoun; Godfrey D. Pearlson

doi:10.1111/j.1530-0277.2010.01332.x

Functional Imaging of Cognitive Control During Acute Alcohol Intoxication

Beth M. Anderson, Michael C. Stevens, Shashwath A. Meda, Kathryn Jordan, Vince D. Calhoun, Godfrey D. Pearlson

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Background: The anterior cingulate and several other prefrontal and parietal brain regions are implicated in error processing and cognitive control. The effects of different doses of alcohol on activity within these brain regions during a functional magnetic resonance imaging (fMRI) task where errors are frequently committed have not been fully explored.Methods: This study examined the impact of a placebo [breath alcohol concentration (BrAC) = 0.00%], moderate (BrAC = 0.05%), and high (BrAC = 0.10%) doses of alcohol on brain hemodynamic activity during a functional MRI (fMRI) Go/No-Go task in 38 healthy volunteers.Results: Alcohol increased reaction time and false alarm errors in a dose-dependent manner. fMRI analyses showed alcohol decreased activity in anterior cingulate, lateral prefrontal cortex, insula, and parietal lobe regions during false alarm responses to No-Go stimuli.Conclusions: These findings indicate that brain regions implicated in error processing are affected by alcohol and might provide a neural basis for alcohol's effects on behavioral performance.

Original language	English (US)
Pages (from-to)	156-165
Number of pages	10
Journal	Alcoholism: Clinical and Experimental Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.1111/j.1530-0277.2010.01332.x
State	Published - Jan 2011
Externally published	Yes

Keywords

Alcohol
Anterior Cingulate
Error Monitoring
Functional Imaging
Go/No-Go

ASJC Scopus subject areas

Medicine (miscellaneous)
Toxicology
Psychiatry and Mental health

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title = "Functional Imaging of Cognitive Control During Acute Alcohol Intoxication",

abstract = "Background: The anterior cingulate and several other prefrontal and parietal brain regions are implicated in error processing and cognitive control. The effects of different doses of alcohol on activity within these brain regions during a functional magnetic resonance imaging (fMRI) task where errors are frequently committed have not been fully explored.Methods: This study examined the impact of a placebo [breath alcohol concentration (BrAC) = 0.00%], moderate (BrAC = 0.05%), and high (BrAC = 0.10%) doses of alcohol on brain hemodynamic activity during a functional MRI (fMRI) Go/No-Go task in 38 healthy volunteers.Results: Alcohol increased reaction time and false alarm errors in a dose-dependent manner. fMRI analyses showed alcohol decreased activity in anterior cingulate, lateral prefrontal cortex, insula, and parietal lobe regions during false alarm responses to No-Go stimuli.Conclusions: These findings indicate that brain regions implicated in error processing are affected by alcohol and might provide a neural basis for alcohol's effects on behavioral performance.",

keywords = "Alcohol, Anterior Cingulate, Error Monitoring, Functional Imaging, Go/No-Go",

author = "Anderson, {Beth M.} and Stevens, {Michael C.} and Meda, {Shashwath A.} and Kathryn Jordan and Calhoun, {Vince D.} and Pearlson, {Godfrey D.}",

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language = "English (US)",

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AU - Stevens, Michael C.

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AU - Jordan, Kathryn

AU - Calhoun, Vince D.

AU - Pearlson, Godfrey D.

PY - 2011/1

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N2 - Background: The anterior cingulate and several other prefrontal and parietal brain regions are implicated in error processing and cognitive control. The effects of different doses of alcohol on activity within these brain regions during a functional magnetic resonance imaging (fMRI) task where errors are frequently committed have not been fully explored.Methods: This study examined the impact of a placebo [breath alcohol concentration (BrAC) = 0.00%], moderate (BrAC = 0.05%), and high (BrAC = 0.10%) doses of alcohol on brain hemodynamic activity during a functional MRI (fMRI) Go/No-Go task in 38 healthy volunteers.Results: Alcohol increased reaction time and false alarm errors in a dose-dependent manner. fMRI analyses showed alcohol decreased activity in anterior cingulate, lateral prefrontal cortex, insula, and parietal lobe regions during false alarm responses to No-Go stimuli.Conclusions: These findings indicate that brain regions implicated in error processing are affected by alcohol and might provide a neural basis for alcohol's effects on behavioral performance.

AB - Background: The anterior cingulate and several other prefrontal and parietal brain regions are implicated in error processing and cognitive control. The effects of different doses of alcohol on activity within these brain regions during a functional magnetic resonance imaging (fMRI) task where errors are frequently committed have not been fully explored.Methods: This study examined the impact of a placebo [breath alcohol concentration (BrAC) = 0.00%], moderate (BrAC = 0.05%), and high (BrAC = 0.10%) doses of alcohol on brain hemodynamic activity during a functional MRI (fMRI) Go/No-Go task in 38 healthy volunteers.Results: Alcohol increased reaction time and false alarm errors in a dose-dependent manner. fMRI analyses showed alcohol decreased activity in anterior cingulate, lateral prefrontal cortex, insula, and parietal lobe regions during false alarm responses to No-Go stimuli.Conclusions: These findings indicate that brain regions implicated in error processing are affected by alcohol and might provide a neural basis for alcohol's effects on behavioral performance.

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Functional Imaging of Cognitive Control During Acute Alcohol Intoxication

Abstract

Keywords

ASJC Scopus subject areas

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