Abstract
The formation of diverse immunoglobulin genes results in part from Rag protein-mediated DNA double-strand breaks at the edges of immunoglobulin gene segments, followed by combinatorial reassembly of these segments. We report that a Transib transposase from the insect Helicoverpa zea is active in vitro and that its breakage and joining activities mimic those of Rag, providing strong evidence that Rag and Transib transposases were derived from a common progenitor.
Original language | English (US) |
---|---|
Pages (from-to) | 834-836 |
Number of pages | 3 |
Journal | Nature Structural and Molecular Biology |
Volume | 19 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2012 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology