Functional brain changes in presymptomatic Huntington's disease

Sarah A.J. Reading, Adam C. Dziorny, Laura A. Peroutka, Mathew Schreiber, Lisa M. Gourley, Venu Yallapragada, Adam Rosenblatt, Russell L. Margolis, James J. Pekar, Godfrey D. Pearlson, Elizabeth Aylward, Jason Brandt, Susan S. Bassett, Christopher A. Ross

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Evidence suggests early structural brain changes in individuals with the Huntington's disease (HD) genetic mutation who are presymptomatic for the movement symptoms of the illness. The aim of this study was to investigate the presence of functional brain changes in this same population using functional magnetic resonance imaging. Subjects and matched controls underwent an functional magnetic resonance imaging "interference" protocol, a task known to be mediated in part by corticostriatal circuitry. In the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifically less activation in the left anterior cingulate cortex (BA 24, 32) compared with matched controls.

Original languageEnglish (US)
Pages (from-to)879-883
Number of pages5
JournalAnnals of neurology
Issue number6
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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