Fructose: Incomplete Intestinal Absorption in Humans

William J. Ravich, Theodore M. Bayless, Miriam Thomas

Research output: Contribution to journalArticlepeer-review

181 Scopus citations


Fructose is an increasingly important commercial sweetener. However, some patients report abdominal symptoms after ingesting fructose-containing foods. The completeness of fructose absorption by the small intestine was assessed by breath hydrogen analysis in 16 healthy volunteers and incomplete absorption was defined as a peak rise in breath hydrogen of 〉20 parts per million. Fructose, 50 g as a 10% solution, was incompletely absorbed in 6 of 16 subjects (37.5%). Incomplete absorption was associated with symptoms of cramps or diarrhea, or both, in 5 of these 6 individuals. Incomplete absorption was both concentration- and dose-related. Three subjects incompletely absorbed 37.5 g of fructose. In comparison, all 15 subjects who were studied after ingestion of sucrose, 50 g as a 10% solution, completely absorbed this sugar load. Incomplete absorption of fructose should be considered as a possible cause of gastrointestinal symptoms.

Original languageEnglish (US)
Pages (from-to)26-29
Number of pages4
Issue number1
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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