From sulfenylation to sulfhydration: What a thiolate needs to tolerate

Toren Finkel

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


There is a growing appreciation that oxidants such as hydrogen peroxide (H 2O 2) and gasses such as nitric oxide (NO) and hydrogen sulfide (H 2S) can act as modulators of various signaling pathways. Much of this signaling occurs through the modifications of specific, critical cysteine residues in target proteins. How such small diffusible molecules (H 2O 2, NO, H 2S) can achieve the required specificity is incompletely understood. Now, new findings provide considerable insight into these and related questions.

Original languageEnglish (US)
Article numberpe10
JournalScience Signaling
Issue number215
StatePublished - Mar 13 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology


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