From structure to disease: The evolving tale of aquaporin biology

Landon S. King; David Kozono; Peter Agre

doi:10.1038/nrm1469

From structure to disease: The evolving tale of aquaporin biology

Landon S. King, David Kozono, Peter Agre

School of Medicine

Research output: Contribution to journal › Review article › peer-review

700 Scopus citations

Abstract

Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins - the aquaporins. These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis. The recognition of aquaporins has stimulated a reconsideration of membrane water permeability by investigators across a wide range of disciplines.

Original language	English (US)
Pages (from-to)	687-698
Number of pages	12
Journal	Nature Reviews Molecular Cell Biology
Volume	5
Issue number	9
DOIs	https://doi.org/10.1038/nrm1469
State	Published - Sep 2004

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nrm1469

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title = "From structure to disease: The evolving tale of aquaporin biology",

abstract = "Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins - the aquaporins. These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis. The recognition of aquaporins has stimulated a reconsideration of membrane water permeability by investigators across a wide range of disciplines.",

author = "King, {Landon S.} and David Kozono and Peter Agre",

note = "Funding Information: The authors receive support from the National Heart, Lung and Blood Institute (L.S.K. and P.A.) and the National Eye Institute (P.A.) of the National Institutes of Health, USA, and from the American Heart Association (L.S.K.).",

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AU - Agre, Peter

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AB - Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins - the aquaporins. These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis. The recognition of aquaporins has stimulated a reconsideration of membrane water permeability by investigators across a wide range of disciplines.

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From structure to disease: The evolving tale of aquaporin biology

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