From Krebs to clinic: Glutamine metabolism to cancer therapy

Brian J. Altman, Zachary E. Stine, Chi V. Dang

Research output: Contribution to journalReview articlepeer-review

665 Scopus citations


The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

Original languageEnglish (US)
Pages (from-to)619-634
Number of pages16
JournalNature Reviews Cancer
Issue number10
StatePublished - Sep 23 2016
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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