From foe to friend: Using animal toxins to investigate ion channel function

Jeet Kalia, Mirela Milescu, Juan Salvatierra, Jordan Wagner, Julie K. Klint, Glenn F. King, Baldomero M. Olivera, Frank Bosmans

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


Ion channels are vital contributors to cellular communication in a wide range of organisms, a distinct feature that renders this ubiquitous family of membrane-spanning proteins a prime target for toxins found in animal venom. For many years, the unique properties of these naturally occurring molecules have enabled researchers to probe the structural and functional features of ion channels and to define their physiological roles in normal and diseased tissues. To illustrate their considerable impact on the ion channel field, this review will highlight fundamental insights into toxin-channel interactions and recently developed toxin screening methods and practical applications of engineered toxins.

Original languageEnglish (US)
Pages (from-to)158-175
Number of pages18
JournalJournal of molecular biology
Issue number1
StatePublished - Jan 16 2015


  • animal toxin
  • screening approaches
  • toxin engineering
  • transient receptor potential channel
  • voltage-gated ion channel

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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