@article{a84a30e2275f428a99ad9d2ed7f99102,
title = "From foe to friend: Using animal toxins to investigate ion channel function",
abstract = "Ion channels are vital contributors to cellular communication in a wide range of organisms, a distinct feature that renders this ubiquitous family of membrane-spanning proteins a prime target for toxins found in animal venom. For many years, the unique properties of these naturally occurring molecules have enabled researchers to probe the structural and functional features of ion channels and to define their physiological roles in normal and diseased tissues. To illustrate their considerable impact on the ion channel field, this review will highlight fundamental insights into toxin-channel interactions and recently developed toxin screening methods and practical applications of engineered toxins.",
keywords = "animal toxin, screening approaches, toxin engineering, transient receptor potential channel, voltage-gated ion channel",
author = "Jeet Kalia and Mirela Milescu and Juan Salvatierra and Jordan Wagner and Klint, {Julie K.} and King, {Glenn F.} and Olivera, {Baldomero M.} and Frank Bosmans",
note = "Funding Information: We would like to thank Kenton J Swartz (National Institute of Neurological Disorders and Stroke of the National Institutes of Health) for making the data shown in Fig. 1 available. We would also like to thank Marie-France Martin-Eauclaire and Pierre E Bougis (University of Marseille) for sharing AaHII and CssII for conducting experiments shown in Fig. 2 and the members of David Julius's and Yifan Cheng's laboratories (University of California, San Francisco) for sharing an image of the TRPV1 structure shown in Fig. 3 . This work was supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under award number R00NS073797 (F.B.), by the National Institute of General Medical Sciences Grant GM48677 (B.M.O.), by the American Heart Association (AHA 13SDG14570024 ) (MM), and the Australian National Health and Medical Research Council (Principal Research Fellowship and Project Grant APP1034958 to G.F.K.). Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2015",
month = jan,
day = "16",
doi = "10.1016/j.jmb.2014.07.027",
language = "English (US)",
volume = "427",
pages = "158--175",
journal = "Journal of molecular biology",
issn = "0022-2836",
publisher = "Academic Press Inc.",
number = "1",
}