TY - JOUR
T1 - From estrogen to androgen receptor
T2 - A new pathway for sex hormones in prostate
AU - Yeh, Shuyuan
AU - Miyamoto, Hiroshi
AU - Shima, Hiroki
AU - Chang, Chawnshang
PY - 1998/5/12
Y1 - 1998/5/12
N2 - While all three coactivators ARA70, steroid receptor coactivator 1, and RAC3/ACTR can enhance androgen receptor (AR) transcriptional activity at 1 nM dihydrotestosterone, we here demonstrate that only ARA70 can induce AR transcriptional activity >30-fold in the presence of 10 nM 17β-estradiol (E2), but not diethylstilbestrol. The significance of this newly described E2-induced AR transcriptional activity in DU145 human prostate cancer cells was further strengthened by finding patients with Reifenstein partial- androgen-insensitive syndrome that fail in the E2-AR-ARA70 pathway. Together, our data suggest, for the first time, testosterone/dihydrotestosterone may not be the only ligands for the AR. E2 represents another important natural ligand for AR that may play an essential role for the AR function and the development of the male reproductive system.
AB - While all three coactivators ARA70, steroid receptor coactivator 1, and RAC3/ACTR can enhance androgen receptor (AR) transcriptional activity at 1 nM dihydrotestosterone, we here demonstrate that only ARA70 can induce AR transcriptional activity >30-fold in the presence of 10 nM 17β-estradiol (E2), but not diethylstilbestrol. The significance of this newly described E2-induced AR transcriptional activity in DU145 human prostate cancer cells was further strengthened by finding patients with Reifenstein partial- androgen-insensitive syndrome that fail in the E2-AR-ARA70 pathway. Together, our data suggest, for the first time, testosterone/dihydrotestosterone may not be the only ligands for the AR. E2 represents another important natural ligand for AR that may play an essential role for the AR function and the development of the male reproductive system.
KW - ACTR
KW - ARA70
KW - Androgen receptor coactivator
KW - RAC3
KW - SRC-1
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U2 - 10.1073/pnas.95.10.5527
DO - 10.1073/pnas.95.10.5527
M3 - Article
C2 - 9576916
AN - SCOPUS:0032510686
SN - 0027-8424
VL - 95
SP - 5527
EP - 5532
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 10
ER -