Abstract
Illuminating compartmentalized signaling: We discuss the applications of FRET-based biosensors with a focus on understanding compartmentalized signaling of kinase and second-messenger dynamics. With their unique features of genetic encodability and targetability, these biosensors allow real-time tracking of activity dynamics with high spatiotemporal resolution. (Figure Presented).
Original language | English (US) |
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Pages (from-to) | 147-151 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Jan 25 2010 |
Keywords
- Biosensors
- FRET
- Kinases
- Second messenger
- Signaling compartmentation
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Molecular Medicine
- Molecular Biology