Frequency of Smad gene mutations in human cancers

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265 Scopus citations

Abstract

Much excitement has recently been generated by the discovery of the Smad genes, encoding proteins that transduce signals from the transforming growth factor β family of cytokines. Here, we report the completion of cloning of the six known human Smads, providing novel sequences for Smad5 and Smad6. Previously, Smad4 and Smad2 were shown to be mutated in human cancers. However, analysis of the other four Smad genes revealed no mutations in a total of 167 tumors, including those from colon, breast, lung, and pancreas. These results suggest that the various Smad genes have different functions and demonstrate that mutations in these four genes do not, in general, account for the widespread resistance to transforming growth factor β that is found in human tumors.

Original languageEnglish (US)
Pages (from-to)2578-2580
Number of pages3
JournalCancer Research
Volume57
Issue number13
StatePublished - Jul 1 1997

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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