TY - JOUR
T1 - Frequency and Distribution of Ophthalmic Surgical Procedures among Patients with Inherited Retinal Diseases
AU - Mees, Lukas
AU - Li, Mingyi
AU - Antonio-Aguirre, Bani
AU - Liu, Tin Yan Alvin
AU - Wu, Adela
AU - Kong, Xiangrong
AU - Singh, Mandeep S.
N1 - Publisher Copyright:
© 2024 American Academy of Ophthalmology
PY - 2024/9
Y1 - 2024/9
N2 - Objective: In this study, we aimed to characterize the frequency and distribution of ocular surgeries in patients with inherited retinal diseases (IRDs) and evaluate associated patient and disease factors. Design: Retrospective cohort. Participants: Subjects aged ≥ 18 years who were followed at the Johns Hopkins Genetic Eye Disease Center. Methods: We studied a retrospective cohort of patients with an IRD diagnosis to analyze the occurrence of laser and incisional surgeries. Subjects were categorized into 2 groups: central dysfunction (macular/cone/cone-rod dystrophy, “MCCRD group”) and panretinal or peripheral dysfunction (retinitis pigmentosa–like, “RP group”). Genetic testing status was recorded. The association of patient and disease factors on the frequency, distribution, and timing of surgeries was analyzed. Main Outcome Measures: Prevalence, prevalence odds ratio (POR), hazard ratio (HR) of ophthalmic procedures by phenotype. Results: A total of 1472 eyes of 736 subjects were evaluated. Among them, 31.3% (n = 230) had undergone ocular surgery, and 78.3% of those (n = 180/230) had a history of more than 1 surgery. A total of 602 surgical procedures were analyzed. Cataract extraction with intraocular lens implantation (CEIOL) was the most common (51.2%), followed by yttrium aluminum garnet capsulotomy, refractive surgery, retinal surgery, and others. Cataract extraction with intraocular lens implantation occurred more frequently in RP than in MCCRD subjects (POR, 2.59; P = 0.002). Retinitis pigmentosa subjects underwent CEIOL at a younger age than patients with MCCRD (HR, 2.11; P < 0.001). Conclusions: Approximately one-third of patients with IRD had a history of laser or incisional surgery. Cataract extraction with intraocular lens implantation was the most common surgery; its frequency and timing may be associated with the IRD phenotype. This data may inform the design of prospective research. Such efforts may illuminate routine clinical decision-making and contribute to surgical strategy development for cell and gene therapy delivery. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
AB - Objective: In this study, we aimed to characterize the frequency and distribution of ocular surgeries in patients with inherited retinal diseases (IRDs) and evaluate associated patient and disease factors. Design: Retrospective cohort. Participants: Subjects aged ≥ 18 years who were followed at the Johns Hopkins Genetic Eye Disease Center. Methods: We studied a retrospective cohort of patients with an IRD diagnosis to analyze the occurrence of laser and incisional surgeries. Subjects were categorized into 2 groups: central dysfunction (macular/cone/cone-rod dystrophy, “MCCRD group”) and panretinal or peripheral dysfunction (retinitis pigmentosa–like, “RP group”). Genetic testing status was recorded. The association of patient and disease factors on the frequency, distribution, and timing of surgeries was analyzed. Main Outcome Measures: Prevalence, prevalence odds ratio (POR), hazard ratio (HR) of ophthalmic procedures by phenotype. Results: A total of 1472 eyes of 736 subjects were evaluated. Among them, 31.3% (n = 230) had undergone ocular surgery, and 78.3% of those (n = 180/230) had a history of more than 1 surgery. A total of 602 surgical procedures were analyzed. Cataract extraction with intraocular lens implantation (CEIOL) was the most common (51.2%), followed by yttrium aluminum garnet capsulotomy, refractive surgery, retinal surgery, and others. Cataract extraction with intraocular lens implantation occurred more frequently in RP than in MCCRD subjects (POR, 2.59; P = 0.002). Retinitis pigmentosa subjects underwent CEIOL at a younger age than patients with MCCRD (HR, 2.11; P < 0.001). Conclusions: Approximately one-third of patients with IRD had a history of laser or incisional surgery. Cataract extraction with intraocular lens implantation was the most common surgery; its frequency and timing may be associated with the IRD phenotype. This data may inform the design of prospective research. Such efforts may illuminate routine clinical decision-making and contribute to surgical strategy development for cell and gene therapy delivery. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
KW - Cataract extraction
KW - Retinal dystrophies
KW - Vitrectomy
KW - cell therapy
KW - gene therapy
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U2 - 10.1016/j.oret.2024.03.005
DO - 10.1016/j.oret.2024.03.005
M3 - Article
C2 - 38485090
AN - SCOPUS:85193034523
SN - 2468-7219
VL - 8
SP - 924
EP - 931
JO - Ophthalmology Retina
JF - Ophthalmology Retina
IS - 9
ER -