Fragile X chromosome frequency is consistent temporally and within replicate cultures

E. C. Jenkins, B. R. Kastin, M. S. Krawczun, K. P. Lele, W. P. Silverman, W. T. Brown

Research output: Contribution to journalArticlepeer-review


Fragile X frequencies differ widely between different fra(X)-positive individuals. The basis for this variation is unknown, but may reflect genetic differences or unknown environmental factors. To determine more fully the individual and familial variation in fra(X) frequencies, we studied 15 individuals. The present study showed that fra(X) frequency, with few exceptions, was consistent for the same individual both over time and within replicate cultures. This confirms previous observations by others on the consistency of fra(X) expression by others, and indicates the extent of expected variability within replicate cultures. Consideration of this variability should enable improved fra(X) identification.

Original languageEnglish (US)
Pages (from-to)475-481
Number of pages7
JournalAmerican journal of medical genetics
Issue number1-2
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)


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