Fractional anisotropy in individuals with schizophrenia and their nonpsychotic siblings

Michael P. Harms; Kazi D. Akhter; John G. Csernansky; Susumu Mori; Deanna M. Barch

doi:10.1016/j.pscychresns.2014.10.009

Fractional anisotropy in individuals with schizophrenia and their nonpsychotic siblings

Michael P. Harms, Kazi D. Akhter, John G. Csernansky, Susumu Mori, Deanna M. Barch

School of Medicine

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9 Scopus citations

Abstract

Fractional anisotropy (FA) was examined in a priori selected fiber tracts in individuals with schizophrenia (. n=25) and their non-psychotic siblings (. n=29) versus controls (. n=35). FA was reduced in a portion of the fornix in individuals with schizophrenia (although this did not survive correction for the number of tracts investigated). FA in the siblings did not differ from that in controls in any of the investigated tracts. •Fractional anisotropy (FA) was compared in individuals with schizophrenia and their siblings versus controls.•FA was reduced in a portion of the fornix in schizophrenia.•FA in siblings did not differ from that in controls.

Original language	English (US)
Pages (from-to)	87-91
Number of pages	5
Journal	Psychiatry Research - Neuroimaging
Volume	231
Issue number	1
DOIs	https://doi.org/10.1016/j.pscychresns.2014.10.009
State	Published - Jan 30 2015

Keywords

Diffusion tensor imaging (DTI)
Endophenotype
Schizophrenia

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/j.pscychresns.2014.10.009

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abstract = "Fractional anisotropy (FA) was examined in a priori selected fiber tracts in individuals with schizophrenia (. n=25) and their non-psychotic siblings (. n=29) versus controls (. n=35). FA was reduced in a portion of the fornix in individuals with schizophrenia (although this did not survive correction for the number of tracts investigated). FA in the siblings did not differ from that in controls in any of the investigated tracts. •Fractional anisotropy (FA) was compared in individuals with schizophrenia and their siblings versus controls.•FA was reduced in a portion of the fornix in schizophrenia.•FA in siblings did not differ from that in controls.",

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AU - Akhter, Kazi D.

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AU - Barch, Deanna M.

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Fractional anisotropy in individuals with schizophrenia and their nonpsychotic siblings

Abstract

Keywords

ASJC Scopus subject areas

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