Four novel HLA class II alleles identified using next-generation sequencing

Alison Gareau; Ahmad Abu-Khader; Guang Yang; Luz Stamm; Noureddine Berka

doi:10.1111/tan.14338

Four novel HLA class II alleles identified using next-generation sequencing

Alison Gareau, Ahmad Abu-Khader, Guang Yang, Luz Stamm, Noureddine Berka

Research output: Contribution to journal › Article › peer-review

Abstract

We describe here four novel HLA class II alleles, DPA1*01:33, DPB1*1082:01, DPB1*1144:01, and DQA1*01:45, identified in our laboratory following the implementation of next generation sequencing (NGS) for routine high resolution HLA typing of donors and recipients for solid organ transplant and hematopoetic stem cell transplant. The NGS technology has improved our ability to match at all clinically HLA loci and to facilitate the interpretation of allele specific antibody and eplet matching.

Original language	English (US)
Pages (from-to)	233-234
Number of pages	2
Journal	HLA
Volume	98
Issue number	3
DOIs	https://doi.org/10.1111/tan.14338
State	Published - Sep 2021
Externally published	Yes

Keywords

CLASS II
NGS
novel alleles

ASJC Scopus subject areas

Genetics
Immunology and Allergy
Immunology

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10.1111/tan.14338

Cite this

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title = "Four novel HLA class II alleles identified using next-generation sequencing",

abstract = "We describe here four novel HLA class II alleles, DPA1*01:33, DPB1*1082:01, DPB1*1144:01, and DQA1*01:45, identified in our laboratory following the implementation of next generation sequencing (NGS) for routine high resolution HLA typing of donors and recipients for solid organ transplant and hematopoetic stem cell transplant. The NGS technology has improved our ability to match at all clinically HLA loci and to facilitate the interpretation of allele specific antibody and eplet matching.",

keywords = "CLASS II, NGS, novel alleles",

author = "Alison Gareau and Ahmad Abu-Khader and Guang Yang and Luz Stamm and Noureddine Berka",

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year = "2021",

month = sep,

doi = "10.1111/tan.14338",

language = "English (US)",

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AU - Abu-Khader, Ahmad

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AU - Stamm, Luz

AU - Berka, Noureddine

PY - 2021/9

Y1 - 2021/9

N2 - We describe here four novel HLA class II alleles, DPA1*01:33, DPB1*1082:01, DPB1*1144:01, and DQA1*01:45, identified in our laboratory following the implementation of next generation sequencing (NGS) for routine high resolution HLA typing of donors and recipients for solid organ transplant and hematopoetic stem cell transplant. The NGS technology has improved our ability to match at all clinically HLA loci and to facilitate the interpretation of allele specific antibody and eplet matching.

AB - We describe here four novel HLA class II alleles, DPA1*01:33, DPB1*1082:01, DPB1*1144:01, and DQA1*01:45, identified in our laboratory following the implementation of next generation sequencing (NGS) for routine high resolution HLA typing of donors and recipients for solid organ transplant and hematopoetic stem cell transplant. The NGS technology has improved our ability to match at all clinically HLA loci and to facilitate the interpretation of allele specific antibody and eplet matching.

KW - CLASS II

KW - NGS

KW - novel alleles

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Four novel HLA class II alleles identified using next-generation sequencing

Abstract

Keywords

ASJC Scopus subject areas

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