Four-dimensional photoacoustic imaging of moving targets

Pinhas Ephrat, Michael Roumeliotis, Frank S. Prato, Jeffrey J.L. Carson

Research output: Contribution to journalArticlepeer-review

Abstract

Photoacoustic imaging provides optical contrast with improved tissue penetration and spatial resolution compared to pure optical techniques. Three-dimensional photoacoustic imaging is particularly advantageous for visualizing non-planar light absorbing structures, such as blood vessels, internal organs or tumours. We have developed a fast 3-D photoacoustic imaging system for small animal research based on a sparse array of ultrasonic detectors and iterative image reconstruction. The system can acquire 3-D images with a single laser-shot at a frame rate of 10 Hz. To demonstrate the imaging capabilities we have constructed phantoms made of a scanning point source and a rotating line object and imaged them at a rate of 10 frames per second. The resulting 4-D photoacoustic images depicted well the motion of each target. Comparison of the perceived motion in the images with the known velocity of the target showed good agreement. To our knowledge, this is the first report of single-shot high frame-rate 3-D photoacoustic imaging system. With further developments, this system could bring to bear its inherent speed for applications in small animal research, such as motion tracking of tumour outline during respiration, and rapid monitoring of contrast agent kinetics.

Original languageEnglish (US)
Pages (from-to)21570-21581
Number of pages12
JournalOptics Express
Volume16
Issue number26
DOIs
StatePublished - Dec 22 2008
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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