Formation and repair of interstrand cross-links in DNA

David M. Noll, Tracey McGregor Mason, Paul S. Miller

Research output: Contribution to journalReview articlepeer-review

372 Scopus citations


A better understanding of the mechanisms of DNA interstrand cross-link repair can lead to more effective strategies for the treatment of cancer and/or the design of drugs that produce interstrand crosslinks that can evade repair. This review focuses on DNA interstrand crosslinks for which there is a substantial body of information about their repair. These include interstrand cross-links produced by nitrogen mustards, mitomycin C, platinum compounds and psoralen. First, the formation and structures of these crosslinks are described. Second, the mechanism of repair of these cross-links as derived from both genetic studies and experiments in cell-free systems is discussed as they occur in both prokaryotic and eukaryotic organisms.

Original languageEnglish (US)
Pages (from-to)277-301
Number of pages25
JournalChemical Reviews
Issue number2
StatePublished - Feb 2006
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)


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