Abstract
We conducted a prospective study to perform classification according to responder types and follow-up during theophyllin treatment (500 mg/d) in a group of (up to now) 65 patients suffering from sleep apnoea. Changes in the apnoea index (AI) and clinical symptoms were taken as response criteria. A significant AI reduction was seen during a follow-up period of 3 months. At the last control measurement after 6 months no significant change has been detected so far. 10 patients were classified as Type I responders (improvement in initial AI 60%, over the total period at least 25%). No patient had a responder type II profile. 13 patients were non-responders (improvement in initial AI and over the whole period not more than 25%, no improvement in the pattern of clinical symptoms). 13 patients dropped out of the trial due to non-compliance. Side effects typical of theophylline leading to discontinuation of the treatment course occurred in 5 patients. 22 Patients have not yet completed the course at the time of writing. Standardised questioning of patients showed a definite improvement in feeling tone, especially with regard to the tendency to fall asleep during the day and refreshed feeling in the morning. Nocturnal complaints occurred in only a few isolated cases. However, administration of theophyllin retard preparations in evening doses of 500 mg/d remains a meaningful therapeutic approach to sleep apnoea.
Translated title of the contribution | Follow-up during theophyllin treatment with daily evening dose in patients with sleep related breathing disorders |
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Original language | German |
Pages (from-to) | 166-169 |
Number of pages | 4 |
Journal | Pneumologie |
Volume | 47 |
Issue number | SUPPL. 1 |
State | Published - 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine