TY - JOUR
T1 - Follicular variant of papillary thyroid cancer - Encapsulated, nonencapsulated, and diffuse
T2 - Distinct biologic and clinical entities
AU - Gupta, Sachin
AU - Ajise, Oluyomi
AU - Dultz, Linda
AU - Wang, Beverly
AU - Nonaka, Daisuke
AU - Ogilvie, Jennifer
AU - Heller, Keith S.
AU - Patel, Kepal N.
PY - 2012/3
Y1 - 2012/3
N2 - Objective: To examine genotypic and clinical differences between encapsulated, nonencapsulated, and diffuse follicular variant of papillary thyroid carcinoma (EFVPTC, NFVPTC, and diffuse FVPTC, respectively), to characterize the entities and identify predictors of their behavior. Design: Retrospective medical chart review and molecular analysis. Setting: Referral center of a university hospital. Patients: The pathologic characteristics of 484 consecutive patients with differentiated thyroid cancer who underwent surgery by the 3 members of the New York University Endocrine Surgery Associates from January 1, 2007, to August 1, 2010, were reviewed. Forty-five patients with FVPTC and in whom at least 1 central compartment lymph node was removed were included. Main Outcome Measures: Patients with FVPTC were compared in terms of age, sex, tumor size, encapsulation, extrathyroid extension, vascular invasion, central nodal metastases, and the presence or absence of mutations in BRAF, H-RAS 12/13, K-RAS 12/13, N-RAS 12/13, H-RAS 61, K-RAS 61, N-RAS 61, and RET/PTC1. Results: Nopatient with EFVPTC had central lymph node metastasis, and in this group, 1 patient (4.5%) had a BRAF V600E mutation and 2 patients (9%) had RAS mutations. Of the patients with NFVPTC, none had central lymph node metastasis (P>.99) and 2 (11%) had a BRAF V600E mutation (P=.59). Of the patients with diffuse FVPTC, all had central lymph node metastasis (P<.001), and 2 (50%) had a BRAF V600E mutation (P=.06). Conclusions: FVPTC consists of several distinct subtypes. Diffuse FVPTC seems to present and behave in a more aggressive fashion. It has a higher rate of central nodal metastasis and BRAF V600E mutation in comparison with EFVPTC and NFVPTC. Both EFVPTC and NFVPTC behave in a similar fashion. The diffuse infiltrative pattern and not just presence or absence of encapsulation seems to determine the tumor phenotype. Understanding the different subtypes of FVPTC will help guide appropriate treatment strategies.
AB - Objective: To examine genotypic and clinical differences between encapsulated, nonencapsulated, and diffuse follicular variant of papillary thyroid carcinoma (EFVPTC, NFVPTC, and diffuse FVPTC, respectively), to characterize the entities and identify predictors of their behavior. Design: Retrospective medical chart review and molecular analysis. Setting: Referral center of a university hospital. Patients: The pathologic characteristics of 484 consecutive patients with differentiated thyroid cancer who underwent surgery by the 3 members of the New York University Endocrine Surgery Associates from January 1, 2007, to August 1, 2010, were reviewed. Forty-five patients with FVPTC and in whom at least 1 central compartment lymph node was removed were included. Main Outcome Measures: Patients with FVPTC were compared in terms of age, sex, tumor size, encapsulation, extrathyroid extension, vascular invasion, central nodal metastases, and the presence or absence of mutations in BRAF, H-RAS 12/13, K-RAS 12/13, N-RAS 12/13, H-RAS 61, K-RAS 61, N-RAS 61, and RET/PTC1. Results: Nopatient with EFVPTC had central lymph node metastasis, and in this group, 1 patient (4.5%) had a BRAF V600E mutation and 2 patients (9%) had RAS mutations. Of the patients with NFVPTC, none had central lymph node metastasis (P>.99) and 2 (11%) had a BRAF V600E mutation (P=.59). Of the patients with diffuse FVPTC, all had central lymph node metastasis (P<.001), and 2 (50%) had a BRAF V600E mutation (P=.06). Conclusions: FVPTC consists of several distinct subtypes. Diffuse FVPTC seems to present and behave in a more aggressive fashion. It has a higher rate of central nodal metastasis and BRAF V600E mutation in comparison with EFVPTC and NFVPTC. Both EFVPTC and NFVPTC behave in a similar fashion. The diffuse infiltrative pattern and not just presence or absence of encapsulation seems to determine the tumor phenotype. Understanding the different subtypes of FVPTC will help guide appropriate treatment strategies.
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U2 - 10.1001/archoto.2011.1466
DO - 10.1001/archoto.2011.1466
M3 - Article
C2 - 22431868
AN - SCOPUS:84863370412
SN - 0886-4470
VL - 138
SP - 227
EP - 233
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 3
ER -