Folate-conjugated gold nanoparticles for cancer nanotechnology applications

K. S. Brandenburg, A. Shakeri-Zadeh, R. Hashemian, G. A. Mansoori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A need exists to target cancer treatments specifically to the tumor site, without damaging healthy tissue. Folate is an essential nutrient required for DNA replication and is brought into a cell via a folate-receptor, making it an ideal cell surface receptor to specifically target fast growing cancer. A Folate-nanoconjugate was tested for cytotoxicity against two types of cancers cells: HeLa and MCF7. The nanoconjugate itself was not cytotoxic to either cell line. The greatest cell lethality upon stimulation with intense pulsed light was observed in the HeLa cells. The lowest concentration of the nanoconjugate and incubation time that caused the greatest cell death (∼98%) was 5 μg/ml concentration and 4 hours incubation in HeLa cells. The same conditions only caused a cell lethality rate of ∼9% in MCF7 cells. Thus we deduced that the difference in cell lethality would be the greater association and increased internalization of the nanoconjugate in HeLa cells over MCF7 cells.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pages404-407
Number of pages4
StatePublished - 2011
Externally publishedYes
EventNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Duration: Jun 13 2011Jun 16 2011

Publication series

NameTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume3

Conference

ConferenceNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Country/TerritoryUnited States
CityBoston, MA
Period6/13/116/16/11

Keywords

  • Cancer nanotechnology
  • Folate
  • Folate-receptor
  • Gold nanoparticle
  • Photothermal treatment

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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