@inproceedings{a25962189c1d404b8fd22eb2c9398a92,
title = "Folate-conjugated gold nanoparticles for cancer nanotechnology applications",
abstract = "A need exists to target cancer treatments specifically to the tumor site, without damaging healthy tissue. Folate is an essential nutrient required for DNA replication and is brought into a cell via a folate-receptor, making it an ideal cell surface receptor to specifically target fast growing cancer. A Folate-nanoconjugate was tested for cytotoxicity against two types of cancers cells: HeLa and MCF7. The nanoconjugate itself was not cytotoxic to either cell line. The greatest cell lethality upon stimulation with intense pulsed light was observed in the HeLa cells. The lowest concentration of the nanoconjugate and incubation time that caused the greatest cell death (∼98%) was 5 μg/ml concentration and 4 hours incubation in HeLa cells. The same conditions only caused a cell lethality rate of ∼9% in MCF7 cells. Thus we deduced that the difference in cell lethality would be the greater association and increased internalization of the nanoconjugate in HeLa cells over MCF7 cells.",
keywords = "Cancer nanotechnology, Folate, Folate-receptor, Gold nanoparticle, Photothermal treatment",
author = "Brandenburg, {K. S.} and A. Shakeri-Zadeh and R. Hashemian and Mansoori, {G. A.}",
year = "2011",
language = "English (US)",
isbn = "9781439871386",
series = "Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011",
pages = "404--407",
booktitle = "Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011",
note = "Nanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 ; Conference date: 13-06-2011 Through 16-06-2011",
}