Folate and homocysteine metabolism: Therapeutic targets in cardiovascular and neurodegenerative disorders

Mark P. Mattson, Frank Haberman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Individuals with elevated homocysteine levels are at increased risk for cardiovascular disease and stroke, and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases Homocysteine is a modified form of the amino acid methionine that is tightly regulated by enzymes requiring folate. By impairing DNA repair mechanisms and inducing oxidative stress, homocysteine can cause the dysfunction or death of cells in the cardiovascular and nervous systems. Dietary folate stimulates homocysteine removal and may thereby protect cells against disease processes. The enzymes involved in homocysteine and folate metabolism provide novel targets for drug discovery.

Original languageEnglish (US)
Pages (from-to)1923-1929
Number of pages7
JournalCurrent Medicinal Chemistry
Volume10
Issue number19
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Apoptosis
  • Atherosclerosis
  • Dietary folic acid
  • Parkinson's disease
  • Schizophrenia
  • Stem cells

ASJC Scopus subject areas

  • Organic Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • Biochemistry
  • Pharmacology

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