Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

Mark P. Mattson, Thomas B. Shea

Research output: Contribution to journalArticlepeer-review

674 Scopus citations


Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of homocysteine - a cytotoxic sulfur-containing amino acid that can induce DNA strand breakage, oxidative stress and apoptosis. Dietary folate is required for normal development of the nervous system, playing important roles regulating neurogenesis and programmed cell death. Recent epidemiological and experimental studies have linked folate deficiency and resultant increased homocysteine levels with several neurodegenerative conditions, including stroke, Alzheimer's disease and Parkinson's disease. Moreover, genetic and clinical data suggest roles for folate and homocysteine in the pathogenesis of psychiatric disorders. A better understanding of the roles of folate and homocysteine in neuronal homeostasis throughout life is revealing novel approaches for preventing and treating neurological disorders.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalTrends in Neurosciences
Issue number3
StatePublished - Mar 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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