Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer

Kanchan Sonkar; Vinay Ayyappan; Caitlin M. Tressler; Oluwatobi Adelaja; Ruoqing Cai; Menglin Cheng; Kristine Glunde

doi:10.1002/nbm.4112

Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer

Kanchan Sonkar, Vinay Ayyappan, Caitlin M. Tressler, Oluwatobi Adelaja, Ruoqing Cai, Menglin Cheng, Kristine Glunde

School of Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer-related studies have focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylcholine. Fewer and more recent studies have reported on the importance of glycerophosphocholine in cancer. In this review article, we summarize the recent literature on glycerophosphocholine metabolism with respect to its cancer biology and its detection by magnetic resonance spectroscopy applications.

Original language	English (US)
Article number	e4112
Journal	NMR in biomedicine
Volume	32
Issue number	10
DOIs	https://doi.org/10.1002/nbm.4112
State	Published - Oct 1 2019

Keywords

MR spectroscopy (MRS) and spectroscopic imaging (MRSI) methods
applications: cellular and molecular cancer imaging
applications: metastases
cancer
cancer therapy responses
cancer: applications
methods and engineering: cancer

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Spectroscopy

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10.1002/nbm.4112

Cite this

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title = "Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer",

abstract = "Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer-related studies have focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylcholine. Fewer and more recent studies have reported on the importance of glycerophosphocholine in cancer. In this review article, we summarize the recent literature on glycerophosphocholine metabolism with respect to its cancer biology and its detection by magnetic resonance spectroscopy applications.",

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AU - Sonkar, Kanchan

AU - Ayyappan, Vinay

AU - Tressler, Caitlin M.

AU - Adelaja, Oluwatobi

AU - Cai, Ruoqing

AU - Cheng, Menglin

AU - Glunde, Kristine

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N2 - Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer-related studies have focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylcholine. Fewer and more recent studies have reported on the importance of glycerophosphocholine in cancer. In this review article, we summarize the recent literature on glycerophosphocholine metabolism with respect to its cancer biology and its detection by magnetic resonance spectroscopy applications.

AB - Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer-related studies have focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylcholine. Fewer and more recent studies have reported on the importance of glycerophosphocholine in cancer. In this review article, we summarize the recent literature on glycerophosphocholine metabolism with respect to its cancer biology and its detection by magnetic resonance spectroscopy applications.

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Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer

Abstract

Keywords

ASJC Scopus subject areas

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